Two postdoc positions on the biophysics of protein linkers at the Department of Molecular Biology and iNANO 812217
Two postdoc positions on the biophysics of protein linkers at the Department of Molecular Biology and iNANO
Aarhus University invites applications for two postdoc positions on the functional and structural properties of linking domains in proteins based at iNANO and the Department of Molecular Biology and Genetics. The positions are initially for one year with the possibility of extension. The starting date is flexible, but ideally as soon as possible.
Signalling molecules in biology are often tethered together in large macromolecular complexes including protein receptors and downstream kinases. The physical association of the proteins control signalling pathways by creating a local high concentration of protein partners. Despite of its importance in biology, little is known about effective concentrations in tethered complexes. This project will address this problem via a two pronged approach:
1) Development of an assay for measuring effective concentrations in multidomain proteins and supra-molecular complexes. Application of these methods to deduce the physico-chemical principles determining effective concentrations of macromolecules linked by flexible linkers.
2) Structural characterization of A kinase anchoring proteins (AKAP) by NMR spectroscopy and single-molecule FRET, to determine how the structural propensities of these proteins affect effective concentrations of linked enzymes and substrates
The candidate is expected to have a Ph.D. in molecular biology, chemistry, biology, nanoscience or similar, and a good track record of publication. Experience with some of the following techniques will be required: Recombinant protein expression, protein purification, affinity determination of protein complexes, NMR spectroscopy, fluorescence spectroscopy, single molecule FRET techniques and analysis of intrinsically disordered proteins.
For further information contact Magnus Kjærgaard (firstname.lastname@example.org).Application procedure
Short-listing is used. This means that after the deadline for applications – and with the assistance from the assessment committee chairman, and the assessment committee if necessary, – the head of department selects the candidates to be evaluated. All applicants will be notified whether or not their applications have been sent to an expert assessment committee for evaluation. The selected applicants will be informed about the composition of the committee, and each applicant is given the opportunity to comment on the part of the assessment that concerns him/her self. Once the recruitment process is completed a final letter of rejection is sent to the deselected applicants, including the main considerations emphasized during the selection process.
Formalities and salary range
Science and Technology refers to the Ministerial Order on the Appointment of Academic Staff at Danish Universities under the Danish Ministry of Science, Technology and Innovation.
The application must be in English and include a curriculum vitae, degree certificate, a complete list of publications, a statement of future research plans and information about research activities, teaching portfolio and verified information on previous teaching experience (if any). Guidelines for applicants can be found here.
Appointment shall be in accordance with the collective labour agreement between the Danish Ministry of Finance and the Danish Confederation of Professional Associations. Further information on qualification requirements and job content may be found in the Memorandum on Job Structure for Academic Staff at Danish Universities.
Salary depends on seniority as agreed between the Danish Ministry of Finance and the Confederation of Professional Associations.
All interested candidates are encouraged to apply, regardless of their personal background.
All applications must be made online and received by:30.03.2016
Please apply online here
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