Scientific Positions

3-year postdoc position. Effects of alpha-synuclein on electrophysiology and calcium in Parkinson's disease 888906

3-year postdoctoral position on a research project to investigate the effect of intracellular alpha-synuclein aggregation on electrophysiological properties and cytosolic calcium levels in models of Parkinson’s disease

Jensen Group - Neurodegenerative Disease Laboratory at DANDRITE (The Danish Research Institute of Translational Neuroscience, see dandrite.au.dk) is looking for a highly qualified postdoc. DANDRITE is the Danish node of the Nordic EMBL Partnership for Molecular Medicine.

Research Area and Project Description
The Jensen Group has recently made several progresses to understand the effects of intracellular alpha-synuclein aggregates on cellular homeostasis and been awarded a larger 5 year grant to investigate these processes. The aim of the project is to progress our understanding of the pathophysiological effects of alpha-synuclein on neuronal calcium levels and study pathways to remedy such effects.
To achieve this aim, combined electrophysiological and in vivo calcium imaging approaches will be performed in studies also comprising histochemical, biochemical and behavioural analyses.
The applicant will perform electrophysiological experiments in isolated neurons, acute and organotypic brain slice cultures and conduct fluorescence based cytosolic calcium measurements in primary neurons, brain slice cultures and in vivo using cranial window techniques.
The electrophysiological studies will be conducted in close collaboration with Group Leader Sadegh Nabavi’s lab and the in vivo calcium imaging in collaboration with Group Leader Keisuke Yonehara’s group, both at DANDRITE.

Specific competences
• Appointment in this position requires a PhD degree in neuroscience or related subjects.
• Previous experience in electrophysiology in vivo or in vitro, and possibly in vivo calcium imaging.
• The successful applicant is expected to be able to manage the project, develop novel technical approaches, conduct firm, kind and thorough supervision, and be a good team player.

We offer
• An exciting collaborative international research environment at the Danish Research Institute of Translational Neuroscience, DANDRITE and the larger NeuroCampus Aarhus (neurocampus.au.dk).
• A challenging position in an exciting new project addressing important fundamental question on the impact of intracellular protein aggregation on neuron structure/function addressed with novel technical approaches.
• A highly collaborative working environment at the Neurodegenerative Disease Laboratory including specific experimental collaborations with Nabavi Group and Yonehara Group and general collaborations with the wider Neuroscience community at Aarhus University.
• Excellent opportunity for further development of skills in project management, collaborations, experimental techniques, and data dissemination.

Place of Employment and Place of Work
DANDRITE is hosted by Aarhus University and is funded by Lundbeckfonden and Aarhus University
DANDRITE is an interdisciplinary research centre affiliated with two faculties at Aarhus University, the Faculty of Health and the Faculty of Science and Technology. The centre has ties to Aarhus University Hospital.
The project is led by Professor Poul Henning Jensen and the workplace address is:
Department of Biomedicine, Jensen Group - Neurodegenerative Disease Laboratory, Ole Worms Allé 3, Bldg 1171, 8000 Aarhus C, Denmark.

Required qualifications and formalities
• The postdoctoral position is a 3-year fixed-term employment, full-time position with 37 hours per week.
• Preferential starting date is from May 2017, or as soon as possible thereafter.

For further information about the position
Prospective candidates are encouraged to contact Professor Poul Henning Jensen, e-mail: phj@biomed.au.dk.
Required qualifications

Appointment as a postdoc requires academic qualifications at PhD level.

Formalities and references

 

  • Further information on the appointment procedure can be found in the Ministerial Order on the Appointment of Academic Staff at Universities.
  • The appointment is in accordance with the Danish Confederation of Professional Associations (Akademikerne).
  • Remuneration is in accordance with the above, and the Salary agreement catalogue for staff at Health.
  • Further information on qualification requirements and job description can be found in the Memorandum on Job Structure for Academic Staff at Danish Universities (in Danish).

     

    Application

    Applications must be accompanied by a CV, diploma, a list of publications, a research plan as well as a teaching portfolio. A maximum of ten of the publications of greatest relevance to the job must be submitted. If you have an assessment within the same job title (completed after March 1, 2016 at AU, Health), then this can be attached to the application.

    Further information on the application and supplementary materials may be found in the faculty's Guidelines for applicants and Aarhus University's Guidelines on the use of teaching portfolios.

    The assessment committee may decide to include non-submitted material in its assessment. In such cases, the applicant will be informed and obliged to submit material, unless the application is withdrawn.

    Applications submitted through channels other than the online application form below or applications which are not received by the application deadline will not be considered.

    All interested candidates are encouraged to apply, regardless of their personal background.

  • Deadline

    All applications must be made online and received by:

    31.03.2017
    Please apply online here

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