FARMAKOLOGISK INSTITUT

Forskningspublikationer

Bidrag i antologier

Drewes, A.M.: Visceral smerte. In: Smerter - en lærebog . Jensen, T.S.; Dahl, B.D.; Arendt-Nielsen, L. (Eds.). FADLs Forlag, København: pp. 153-69, 2003.

Drewes, A.M.; Arendt-Nielsen, L.; Giamberardino, M.A.: Schmertz mit Ursprung im viszeralen System. Symptome und Behandlung. In: Angewandte Physiologie 4. Schmerzen verstehen und beeinflussen . Van der Berg, F. (Ed.). Thieme, Stuttgart: pp. 157-69, 2003.

Drewes, A.M.; Arendt-Nielsen, L.; Giamberardino, M.A.: Wechselwirkung zwischen viszeralem Scmertz und anderen Structuren. In: Angewandte Physiologie 4. Schmerzen verstehen und beeinflussen . Van der Berg et al (Ed.). Thieme, Stuttgart: pp. 76-89, 2003.

Husted, S.E.; Nielsen, H.K.: Heparins: which to use? In: Drug advances volume one . Grey, J. (Ed.). Remidica, London UK and Lincolnshire USA, 2003.

Lindgren, A.; Husted, S.: Dipyridamole and headache - does dose titration help? In: Update on stroke therapy . Wahlgren, N.G.; Ahmed, N.; Hårdemark, H.-G. (Eds.). Karolinska Stroke Update, Stockholm, 2003.

Artikler i internationale tidsskrifter

Amstrong, P.W.; Wagner, G.; Goodman, S.G.; Van de Werf, F.; Granger, C.; Wallentin, L.; Du, Y.; ASSENT 3 Investigators (Husted, S.E.): ST segment resolution in ASSENT 3: insights into the role of three different treatment strategies for acute myocardial infarction. Eur Heart J ; 24: 1515-22, 2003.

Andersen, H.R.; Nielsen, T.T.; Rasmussen, K.; Thuesen, L.; Kelbaek, H.; Thayssen, P.; Abildgaard, U.; Pedersen, F.; Madsen, J.K.; Grande, P.; Villadsen, A.B.; Krusell, L.R.; Haghfelt, T.; Lomholt, P.; Husted, S.E.; Vigholt, E.; Kjaergaard, H.K.; Mortensen, L.S.: A comparison of coronary angioplasty with fibrinolytic therapy in acute miocardial infarction. N Engl J Med ; 349: 733-42, 2003.

Birkebæk, N.H.; Patel, L.; Wright, N.B.; Grigg, J.R.; Sinha, S.; Hall, C.M.; Price, D.A.; Lloyd, I.C.; Clayton, P.e.: Endocrine status in patientes with optic nerve hypoplasia: Relationship to midline central nervous system abnormalities and appearance of the hypothalamic-pituitary axis on magnetic resonance imaging. J Clin Endocrinol Metab ; 88: 5281-6, 2003.

Devereux, R.B.; Dahlöf, B.; Kjeldsen, S.E.; Julius, S.; Aurup, P.; Beevers, G.; Edelman, J.; de Faire, U.; Fyhrquist, F.; Harris, K.; Ibsen, H.; Kristianson, K.; Lederballe-Pedersen, O.; Lindholm, L.H.; Nieminen, M.S.; Omvik, P.; Oparil, S.; Snappin, S.; Wedel, H.: Effects of losartan or atenolol in hypertensive patients without clinically evident vascular disease: A substudy of the LIFE randomized trial. Ann Intern Med ; 139: 169-77, 2003.

Drewes, A.M.; Babenko, L.; Birket-Smith, L.; Funch-Jensen, P.; Arendt-Nielsen, L.: Induction of non-painful and painful intestinal sensations by hypertonic saline: a new human experimental model. Eur J Pain ; 7: 81-91, 2003.

Drewes, A.M.; Gregersen, H.; Arendt-Nielsen, L.: Experimental pain in gastroenterology. A reappraisal of human studies. Scand J Gastroenterol ; 38: 1115-30, 2003.

Drewes, A.M.; Pedersen, J.; Liu, W.; Arendt-Nielsen, L.; Gregersen, H.: Controlled mechanical distension of the human oesophagus: Sensory and biomechanical findings. Scand J Gastroenterol ; 38: 27-35, 2003.

Drewes, A.M.; Schipper, K-P.; Dimcevski, G.; Petersen, P.; Gregersen, H.; Funch-Jensen, P.; Arendt-Nielsen, L.: Gut pain and hyperalgesia induced by capsaicin: A human experimental model. Pain ; 104: 333-41, 2003.

Dubois, C.L.; Belmans, A.; Granger, C.B.; Amstrong, P.W.; Wallentin, L.; Fioretti P.M.; Lopez-Sendon, J.L.; Verheugt, F.W.; Meyer, J.; Van de Werf, F.; ASSENT-3 Investigators (Husted, S.E.): Outcome of urgent and elective percutaneous coronary interventions after pharmacologic with tenecteplase combined with unfractionated heparin, enoxaparin, or abciximab. J Am Coll Cardiol ; 42: 1178-85, 2003.

Eskildsen-Helmond, Y.E.; Mulvany, M.J.: Pressure-induced activation of extracellular signal-regulated kinase 1/2 in small arteries. Hypertension ; 41(4): 891-7, 2003.

Frystyk, J.; Nyholm, B.; Skjærbæk, C.; Baxter, R.C.; Schmitz, O.; Ørskov, H.: The circulating IGF-system and its relationship with 24-h glucose regulation and insulin sensitivity in healthy subjects. Clin Endocrinol (Oxf) ; (58): 777-84, 2003.

Gao, C.; Arendt-Nielsen, L.; Liu, W.; Petersen, P.; Drewes, A.M.; Gregersen, H.: Biomechanical responses to ramp-controlled distension of the human duodenum. Am J Physiol Gastrointest Liver Physiol ; 284: G461-71, 2003.

Gradin, K.A:; Li, J.; Andersson, O.; Simonsen, U.: Altered neuropeptide Y content and vasoconstriction in female spontaneously hypertensive rats. Journal of Vascl. Res. ; 40: 252-265, 2003.

Gregersen, H.; Drewes, A.M.: Impedance plainmetry for studying the function of the gastrointestinal tract. New Wave ; 5: 4-7, 2003.

Gregersen, S.; Thomsen, J.L.; Jeppesen, P.B.; Alstrup, K.K.; Brock, B.; Pedersen, S.B.; Kristensen, K.; Hermansen, K.: Impact of dietary FA and energy restriction on plasma leptin and ob gene expression in mice. Lipids ; 38: 513-7, 2003.

Grunze, H.; Kasper, S.; Goodwin, G.; Bowden, C.; Baldwin, D.; Licht, R.W.; Vieta, E.; Möller, H.-J.: WFSBP guidelines for biological treatment of bipolar disorders, part II: treatment of mania. World J Biol Psychiatry ; 4: 5-13, 2003.

Hernanz, R.; Alonso, M.J.; Briones, A.M.; Simonsen, U.; Salaices, M.: Mechanisms involved in the early increase of serotonin contraction evoked by endotoxin in rat middle cerebral arteries. Br J Pharmacol ; (140): 671-680, 2003.

Hernández, M.; Barahona, M.V.; Simonsen, U.; Recio, P.; Rivera, L.; Martinez, A.C.; García-Sacristán, A.; Orensanz, L.M.; Prieto, D.: Characterization of the 5-hydroxytryptamine receptors mediating contraction in the pig isolated intravesical ureter. Br. J. Pharmacol. ; 103: 137-144, 2003.

James, S.K.; Armstrong, P.; Barnathan, E.; Califf, P.; Lindahl, B.; Siegbahn, A.; Simoons, M.L.; Topol, E.J.; Venge, P.; Wallentin, L.; GUSTO-IV-ASC Investigators (Husted, S.E.): Tropponin and C-reactive protein have different relations to subsequent mortality and myocardial infarction after acute coronary syndromes: a GUSTO-IV substudy. J Am Coll Cardiol ; 41: 916-24, 2003.

Jessen, N.; Pold, R.; Buhl, E.S.; Jensen, L.S.; Schmitz, O.; Lund, S.: Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles. J Appl Physiol ; 94: 1373-9, 2003.

Johnsen, S.P.; Overvad, K.; Stripp, C.; Tjønneland, A.; Husted, S.E.; Sørensen, H.T.: Intake of fruit and vegetables and the risk of ischemic stroke in a cohort of Danish men and women. Am J Clin Nutr ; 78: 57-64, 2003.

Juhl, C.B.; Hollingdal, M.; Pørksen, N.; Prange, A.; Lønnqvist, F.; Schmitz, O.: Influence of rosiglitazone treatment on beta-cell function in type 2 diabetes: Evidence of an increased ability of glucose to entrain high-frequency insulin pulsatility. J Clin Endocrinol Metab ; 88: 3794-800, 2003.

Karamperis, N.; Povlsen, J.V.; Højskov, C.; Poulsen, J.H.; Pedersen, A.R.; Jørgensen, K.A.: A comparison of the pharmacokinetic properties of tacrolimus and cyclosporine at equivalent molecular dose. Transplant Proceed ; 35: 1314-8, 2003.

Kun, A.; Martinez, A.C.; Tanko, L.; Pataricza, J.; Papp, J.G.; Simonsen, U.: Ca2+-activated K+ channels in the endothelial layer involved in modulation of neurogenic contractions of rat penile arteries. Eur. J. Pharmacol. ; 474: 103-115, 2003.

Kvist, S.; Mulvany, M.J.: Contrasting regression of blood pressure and cardiovascular structure in declipped renovascular hypertensive rats. Hypertension ; 41(3): 540-5, 2003.

Larsen, A.; Martiny, M.; Stoltenberg, M.; Danscher, G.; Rungby, J.: Gastrointestinal and systemic uptake of bismuth in mice after oral exposure. Pharmacol Toxicol ; 93: 82-90, 2003.

Larsen, B.B.; Nielsen, L.P.; Engelstätter, R.; Steinjans, V.; Dahl, R.: Effect of ciclesonide on allergen challenge in subjects with bronchial asthma. Allergy ; 58: 207-12, 2003.

Licht, R.W.; Larsen, J.O.; Smith, D.; Brændgård, H.: Chronic lithium treatment with or without haloperidol fails to affect the morphology of the rat cerebellum. European Neuropsychopharmacology ; 13: 173-6, 2003.

Licht, R.W.; Vestergaard, P.; Larsen, J.K.; Kessing, L.V.; Thomsen, P.H.: Psychoparmacological treatment with lithium and epileptic drugs: suggested guidelines from the Danish Psychiiatric Association and the Child and Adolescent Psyciatric Association in Denmark. Acta Psychiatrica Scandinavica ; 108: 1-22, 2003.

Lihn, A.S.; Østergaard, T.; Nyholm, B.; Pedersen, S.B.; Richelsen, B.; Schmitz, O.: Adiponectin expression in adipose tissue is reduced in first-degree relatives of type 2 diabetic patients. Am J Physiol Endocrinol Metab ; 284(2): E443-8, 2003.

Mortensen, U.M.; Nielsen-Kudsk, J.E.; Jakobsen, P.; Nielsen, T.T.: Glibenclamide blunts coronary flow reserve induced by adenosine and dipyridamole. Scand Cardiovasc J ; Sep(37(5)): 247-52, 2003.

Nielsen, J.C.; Kristensen, L.; Andersen, H.R.; Mortensen, P.T.; Pedersen, O.L.; Pedersen, A.K.: A randomized comparison of atrial and dual-chamber pacing in 177 consecutive patients with sick sinus syndrome. J Am Coll Cardiol ; 42: 614-23, 2003.

Norrelund, H.; Djurhuus, C.; Jorgensen, J.O.; Nielsen, S.; Nair, K.S.; Schmitz, O.; Christiansen, J.S.; Moller, N.: Effects of GH on urea, glucose and lipid metabolism, and insulin sensitivity during fasting in GH-deficient patients. Am J Physiol Endocrinol Metab ; 285: E737-43, 2003.

Ottervanger, J.P.; Armstrong, P.; Barnathan, E.S.; Boersma, E.; Cooper, J.S.; Ohman, E.M.; James, S.; Topol, E.; Wallentin, L.; Simoons, M.L.; GUSTO-IV-ACS Investigators (Husted, S.E.): Long-term results after the glycoprotein Iib/IIIa inhibitor abciximab in anstable angine: one-year survival in the GUSTO-IV-ACS (Global Use Strategies To Open Occluded Coronary Arteries IV - Acute Coronary Syndrome) trial. Circulation ; 107: 437-42, 2003.

Pedersen, J.; Gao, C.; Egekvist, H.; Bjerring, P.; Arendt-Nielsen, L.; Gregersen, H.; Drewes, A.M.: Pain and biomechanical responses to distension of the duodenum in patients with systemic sclerosis. Gastroenterology ; 124: 1230-9, 2003.

Petersen, P.; Gao, C.; Arendt-Nielsen, L.; Gregersen, H.; Drewes, A.M.: Pain intensity and biomechanical responses during ramp-controlled distension of the human rectum. Dig Dis Sci ; 48: 1310-6, 2003.

Porteri, E.; Rizzoni, D.; Mulvany, M.J.; De Ciuceis, C.; Sleiman, I.; Boari, G.E.; Castellano, M.; Muiesan, M.L.; Zani, F.; Rosei, E.A.: Adrenergic mechanisms and remodeling of subcutaneous small resistance arteries in humans. J Hypertens ; Dec(21): 2345-2352, 2003.

Qari, M.; Abdel-Razeq, H.; Alzeer, A.; Alizadeh, H.; Kristensen, J.; Al-Sayegh, F.; Qutub, H.; Marashi, M.; Husted, S.; Mousa, S.: Recent advances in the diagnosis and treatment of deep vein thrombosis: A regional consensus. Current Opinion in Investigational Drugs ; 4: 309-15, 2003.

Randsbaek, F.; Lund, S.; Kimose, H.H.; Grove, E.; Botker, H.E.; Schmitz, O.; Nielsen, T.T.: Angiotensin II inhibition increases cellular glucose transport during reperfusion but not ischemia in pig hearts. Scand Cardiovasc J ; 37: 205-10, 2003.

Rasmussen, L.; Husted, S.E.; Johnsen, S.P.: Severe intoxication after an intentional overdose of amlodipine. Acta Anaest Scand ; 47: 1038-40, 2003.

Rössel, P.; Arendt-Nielsen, L.; Niddam, D.; Chen, A.C.N.; Drewes, A.M.: Short latency cerebral response evoked by painful electrical stimulation applied to the human sigmoid colon and to the convergent referred somatic pain area. Exp Brain Res ; 151: 115-22, 2003.

Sondergaard, L.G.; Stoltenberg, M.; Flyvbjerg, A.; Brock, B.; Schmitz, O.; Danscher, G.; Rungby, J.: Zinc ions in beta-cells of obese, insulin resistant, and type 2 diabetic rats traced by autometallography. APMIS ; 111: 1147-54, 2003.

Sumikura, H.; Andersen, O.K.; Drewes, A.M.; Arendt-Nielsen, L.: Spatial and temporal profiles of flare and hyperalgesia after intradermal capsaicin. Pain ; 105: 285-91, 2003.

Sumukura, H.; Andersen, O.K.; Drewes, A.M.; Arendt-Nielsen, L.: A comparison of hyperalgesia and neurogenic inflammation induced by melittin and capsaicin in humans. Neurisci Lett ; 337: 147-50, 2003.

Thorsgaard, M.; Lopez, V.; Buus, N.H.; Simonsen, U.: Different modulation by Ca 2+-activated K+ channel blockers and herbimycin of acetylcholine and flow-evoked vasodilatation in rat mesenteric small arteries. Br. J. Pharmacol. ; 138: 1562-1570, 2003.

Venge, P.; Johnston, N.; Lagerqvist, B.; Wallentin, L.; Lindahl, B.; FRISC-II Study Group (Husted, S.E.): Clinical and analytical performance of the liaison cardiac troponin I assay in unstable coronary artery disease, and the impact of age on the definition of reference limits. A FRISC-II substudy. Clin Chem ; 49: 880-6, 2003.

Wachtell, K.; Ibsen, H.; Olsen, M.H.; Borch-Johnsen, K.; Lindholm, L.H.; Mogensen, C.E.; Dahlöf, B.; Devereux, R.B.; Beevers, G.; de Faire, U.; Fyhrquist, F.; Julius, S.; Kjeldsen, S.E.; Kristiansson, K.; Lederballe-Pedersen, O.; Nieminen, M.S.; Okin, P.; Omvik, P.; Oparil, S.; Wedel, H.; Snapinn, S.M.; Aurup, P.: Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study. Ann Intern Med ; 139: 901-6, 2003.

Zeuthen, E.; Lassen, J.F.; Husted, S.E.: Is there a hypercoagulable phase during initiation of antithrombotic therapy with oral anticoagulants in patients with atrial fibrillation? Throm Res ; 109: 241-6, 2003.

Artikler i danske tidsskrifter

Birkebæk, N.H.; Schiøtz, P.O.: Østrogen er også nødvendig for drenge og mænd. Ugeskr Laeger ; 165: 1787, 2003.

Ibsen, H.; Lederballe-Pedersen, O.; Dahlöf, B.; Kjeldsen, S.; Lindholm, H.: Virkningen af losartan versus atenolol på kardiovaskulær morbiditet og mortalitet hos patienter med hypertension og ekg-verificeret venstre ventrikelhypertrofi i LIFE-undersøgelsen: Losarta For Endpoint reduction in hypertension study. Ugeskr Laeger ; 165: 456-9, 2003.

Ibsen, H.; Lindholm, L.H.; Lederballe-Pedersen, O.; Dahlöf, B.; Kjeldsen, S.: Virkningen af losartan versus atenolol på kardiovaskulær morbiditet og mortalitet hos patienter med diabetes mellitus i LIFE undersøgensen: Losartan Intervention for Endoint Reduction in Hypertension Study. Ugeskr Laeger ; 165: 459-62, 2003.

Jørgensen, K.A.; Dieperink, H.; Kirkegaard, P.: Komplikationer ved immunosuppressiv behandling ved organtransplantation. Ugeskr Laeger ; 49: 4727-9, 2003.

Loft, A.G.; Tarp, U.; Thomsen, B.S.: Anakinra til behandling af reumatoid artrit. Ugeskr Laeger ; 165: 3720-4, 2003.

Vestergaard, P.; Licht, R.W.: Forebyggende, medikamentel behandling af depressionssygdommen. Ugeskr Laeger ; 165: 2969-70, 2003.

Ziegler, B.K.; Rasmussen, L.H.; Kristensen, S.D.; Hildebrandt, P.R.; Nielsen, H.K.; Husted, S.E.: Clopidogrel: baggrundsinformation og anvendelse i klinisk praksis. Ugeskr Laeger ; 165: 1859-63, 2003.

Reviews, videnskabelige anmeldelser

Gjedde, S.; Christiansen, A.; Pedersen, S.B.; Rungby, J.: Survival following a metformin overdose of 63 g: A case report. Pharmacol Toxicol ; 93: 98-9, 2003.

Jørgensen, K.A.; Koefoed-Nielsen, P.B.; Karamperis, N.: Calcineurin Phosphatase and immunosuppression. A review on the role of calcineurin phosphatase in the immunosuppressive effects of cyclosprine and tacrolimus. Scand J Immunol ; 57: 93-8, 2003.

Laursen, T.: Pharmacological properties of a long-acting preparation of growth hormone. International Growth Monitor ; 13(2): 11-13, 2003.

Nielsen, L.P.; Dahl, R.: Comparison of intranasal corticosteroids and antihistamines in allergic rhinitis. A review of randomised, controlled trials. Am J Respir Med ; 2: 55-65, 2003.

Stankevicius, E.; Kevelaitis, E.; Vainorius, E.; Simonsen, U.: Role of nitric oxide and other endothelium-derived factors. Medicina (Kaunas) ; 39(4): 333-341, 2003.

Letters, kommentarer, videnskabelig debat

Madsbad, S.; Brock, B.; Schmitz, O.: Postprandial hyperglykæmi. Postprandiale blodglukosevirkninger og kardiovaskulær sygdom samt sendiabetiske komplikationer. Ugeskr Laeger ; 165: 3149-53, 2003.

Møller, N.; Schmitz, O.; Mortensen, H.B.; Mandrup-Poulsen, T.; Hommel, E.E.; Parving, H.H.; Mogensen, C.E.: Insulinpumper og diabetesbehandling. Ugeskr Laeger ; 165, 2003.

Nielsen, L.P.; Brock, B.; Poulsen, J.H.: Hvad kan vi bruge den kliniske farmakolog til. Medicus , 2003.

Østergaard, T.; Hansen, T.K.; Nyholm, B.; Gravholt, C.H.; Djurhuus, C.B.; Hosoda, H.; Kangawa, K.; Schmitz, O.: Circulating ghrelin concentrations are reduced in healthy offspring of Type 2 diabetic subjects, and are increased in women independent of a family history of Type 2 diabetes. Diabetologia ; 46: 134-6, 2003.