Farmakologisk Institut

Formidling

Bidrag til forskningsformidlende bog/antologi

Mulvany, M, & Simonsen, U 2005, 'Receptor farmakologi' i: Lægemiddelkatologet, s. 1197-16.

Tidsskriftartikel

Drewes, A 2005, 'Gastro-oesophageal reflukssygdom' Læge-Helse, vol. 10, s. 6-7.

Rungby, J 2005, 'Kommunerne bør ikke stå for endokrinologiske sygdomme' Dagens Medicin, nr. 33.

Rungby, J 2005, 'Hyperglykäemie als Risikofaktor' Medical Tribune, nr. 26.

Rungby, J 2005, 'http://www.servier.com/pro/diabetologie/congres/easd/easd2005_video.asp' Diabetologie.

Avisartikel

Rungby, J 2005, 'Knaldrøde strømper' Politiken.

Forskning

Artikel

Brix-Christensen, V, Vestergaard, C, Andersen, SK, Krog, J, Andersen, NT, Larsson, A, O., S, & Tønnesen, EK 2005, 'Evidence that acute hyperinsulinaemia increases the cytokine content in essential organs after an endotoxin challenge in a porcine model' Acta Anaesthesiologica Scandinavica, vol. 49, s. 1429-1435.

Brix-Christensen, V, Gjedsted, J, Andersen, SK, Vestergaard, C, Nielsen, JS, Rix, T, Nyboe, R, Andersen, NT, Larsson, A, Schmitz, O, & Tønnesen, EK 2005, 'Inflammatory response during hyperglycemia and hyperinsulinemia in a porcine endotoxemic model: the contribution of essential organs' Acta Anaesthesiologica Scandinavica, vol. 49, nr. 7, s. 991-8.

Carstens, J, Markussen, N, & Madsen, M 2005, 'The granule exocytosis and Fas/FasLigand pathways at the time of transplantation and during borderline and acute rejection of human renal allografts' Transplant Proc, vol. 37, nr. 8, s. 3294-3297.

Christensen, K 2005, 'Lægemiddelinformation om lercanidipin - en nyere dihydropyridin calciumantagonist til behandling af arteriel hypertension' Ugeskr Laeger, vol. 167(2), s. 153-155.

Dahl, R, Hofmann, HJ, Bøgebjerg, M, & Nielsen, LP 2005, 'Lysis with Saponin improves detection of the response through CD203c and CD63 in the basophil activation test after crosslinking of the high affinity IgE receptor FcepsilonRI' Clin Mol Allergy.

Drewes, A, & Funch-Jensen, P 2005, 'Hvad er galdestenssmerter?' Ugeskr Laeger, vol. 167, s. 2607-2613.

Drewes, A, Reddy, H, Staahl, C, Pedersen, J, Funch-Jensen, P, Arendt-Nielsen, L, & Gregersen, H 2005, 'Sensory-motor responses to mechanical stimulation of the esophagus after sensitization with acid' World J Gastroenterol, vol. 11, s. 4367-4374.

Drewes, A, Rössel, P, Le Pera, D, Arendt-Nielsen, L, & Valeriani, M 2005, 'Cortical neuroplastic changes to painful colon stimulation in patients with irritable bowel syndrome' Neurosci Lett, vol. 375, s. 157-161.

Drewes, A 2005, 'Gastro-oesophageal reflukssygdom' Overblik, vol. 10, nr. 6, s. 6-7.

Drewes, A, Reddy, H, Staahl, C, Pedersen, J, Jensen, PF, Arendt-Nielsen, L, & Gregersen, H 2005, 'Sensory-motor responses to mechanical stimulation of the esophagus after sensitization with acid' World J Gastroenterol, vol. 11, nr. 28, s. 4367-4374.

Drewes, A, Reddy, H, Staahl, C, Funch-Jensen, P, Arendt-Nielsen, L, Gregersen, H, & Lundbye-Christensen, S 2005, 'Statistical modeling of the response characteristics of mechanosensitive stimuli in the human esophagus' J Pain, vol. 6, s. 544-562.

Frøbert, O, Buus, CL, & Rembold, C 2005, 'HSP20 phosphorylation and interstitial metabolites in hypoxia-induced dilation of swine coronary arteries' Acta Physiol Scand, vol. 184, nr. 1, s. 37-44.

Frøkjær, J, Andersen, S, Gale, J, Arendt-Nielsen, L, Gregersen, H, & Drewes, A 2005, 'An experimental study of viscero-visceral hyperalgesia using an ultrasound-based multimodal sensory testing approach' Pain, vol. 119, s. 191-200.

Frøkjær, J, Larsen, E, Steffensen, E, Nielsen, A, & Drewes, A 2005, 'Magnetic resonance imaging of the small bowel in Crohn's disease' Scand J Gastroenterol, vol. 40, s. 832-842.

Frøkjær, J, Liao, D, Bergmann, A, McMahon, B, Steffensen, E, Drewes, A, & Gregersen, H 2005, 'Three-dimensional biomechanical properties of the human rectum evaluated with magnetic resonance imaging' Neurogastroenterol Motil, vol. 17, s. 531-540.

Karamperis, N, Koefoed-Nielsen, P, Højskov, C, Poulsen, J, & Jørgensen, K 2005, 'Impact of metabolites and calcineurin inhibition on C2 monitoring in renal transplant patients' Nephrol Dial Transplant, vol. 20, s. 618-621.

Koefoed-Nielsen, P, Karamperis, N, Højskov, C, Poulsen, J, & Jørgensen, K 2005, 'A comparison of the temporal profile of calcineurin inhibition by cyclosporine and tacrolimus in renal transplanted patients' Transplant Proceed, vol. 37, s. 1736-1738.

Koefoed-Nielsen, P, Karamperis, N, & Jørgensen, K 2005, '24-hour monitoring of calcineurin phosphatase activity in healthy subjects' Scand J Immunol, vol. 62, s. 309-311.

Madsen, MM, Busk, M, Søndergaard, HM, Bøttcher, M, Mortensen, L, Andersen, HR, & Nielsen, TT 2005, 'Does diabetes mellitus abolish the beneficial effect of primary coronary angioplasty on long-term risk of reinfarction after acute ST-segment elevation myocardial infarction compared with fibrinolysis?: A DANAMI-2 substudy' Am J Cardiol, vol. 96, nr. 11, s. 1469-75.

McMahon, B, Frøkjær, J, Liao, D, Kunwald, P, Drewes, A, & Gregersen, H 2005, 'A new technique for evaluating sphincter function in visceral organs application of the functional lumen imaging probe (FLIP) for the evaluation of the oesophagogastric junction' Physiol Meas, vol. 26, s. 823-836.

McMahon, B, Frøkjær, J, Liao, D, Kunwald, P, Drewes, A, & Gregersen, H 2005, 'A new technique for evaluating sphincter function in visceral organs: application of the functional lumen imaging probe (FLIP) for the evaluation of the oesophago-gastric junction' Physiol Meas, vol. 26, nr. 5, s. 823-836.

Nielsen, L, Sami, A, Drewes, A, Nielsen, K, & Gaihede, M 2005, 'Central control of human middle ear pressure. Preliminary evidence based on brain evoked potentials' Otology & Neurotology, vol. 26, s. 305-306.

Nielsen, L, & Madsen, F 2005, 'Farmakoterapi ved allergisk sygdom' Ugeskr Laeger, vol. 167(6), s. 661-663.

Pedersen, J, Drewes, A, & Gregersen, H 2005, 'New analysis for the study of the muscle function in the human oesophagus' Neurogastroenterol Motil, vol. 17, nr. 5, s. 767-772.

Reddy, H, Arendt-Nielsen, L, Staahl, C, Pedersen, J, Funch-Jensen, P, Gregersen, H, & Drewes, A 2005, 'Gender differences in pain and biomechanical responses after acid sensitization of the human esophagus' Dig Dis Sci, vol. 50, s. 2050-2058.

Reddy, H, Arendt-Nielsen, L, Staahl, C, Jensen, PF, Gregersen, H, & Drewes, A 2005, 'Gender differences in pain and biomechanical responses after acid sensitization of the human esophagus' Dig Dis Sci, vol. 50, nr. 11, s. 2050-2058.

Schmitz, O, & Brock, B 2005, 'Stages of evolving beta-cell dysfunction during progression of type 2 diabetes' Medicographia, vol. 27(4), s. 299-306.

Stawowy, M, Funch-Jensen, P, Arendt-Nielsen, L, & Drewes, A 2005, 'Somatosensory changes in the referred pain area in patients with cholecystitis' Eur J Gastroenterol Hepatol, vol. 17, s. 865-870.

Artikel peer reviewed

Andersen, C, Mulvany, M, & Simonsen, U 2005, 'Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats' Eur J Pharmacol, vol. 510(1-2), s. 87-96.

Andersen, H, Schmitz, O, & Nielsen, S 2005, 'Decreased isometric muscle strength after acute hyperglycemia in Type 1 diabetic patients' Diabet Med, vol. 22(10), s. 1401-1407.

B., EL, Mulvany, M, & Simonsen, U 2005, 'Dual impact of a nitric oxide donor, GEA 3175, in human pulmonary smooth muscle' Eur J Pharmacol, vol. 516(1), s. 78-84.

B.K., A, Hasle, H, Clausen, N, Schroder, H, & Jakobsen, P 2005, 'Pain intensity and bioavailability of intramuscular asparaginase and a local anesthetic: a double-blinded study' Pediatr Blood Cancer, vol. 44(3), s. 255-258.

Bakker, E, Buus, C, Spaan, J, Perree, J, Ganga, A, Rolf, T, Sorop, O, Bramsen, L, Mulvany, M, & Vanbavel, E 2005, 'Small artery remodeling depends on tissue-type transglutaminase' Circ Res, vol. 96(1), s. 119-126.

Brock, B, Schmidt, K, Ovesen, P, Schmitz, O, & Rungby, J 2005, 'Is metformin therapy for polycystic ovary syndrome safe during pregnancy?' Basic Clin Pharmacol Toxicol, vol. 96, nr. 6, s. 410-2.

Dahl, R, Nielsen, L, Kips, J, Foresi, A, Cauwenberge, P, Tudoric, N, Howarth, P, Richards, D, Williams, M, Pauwels, R, & nullStudyGroup, S 2005, 'Intranasal and inhaled fluticasone propionate for pollen-induced rhinitis and asthma' Allergy, vol. 60(7), s. 875-881.

Dormandy, J, Charbonnel, B, Eckland, D, Erdmann, E, Massi-Benedetti, M, Moules, I, Skene, A, Tan, M, Lefebvre, P, Murray, G, Standl, E, Wilcox, R, Wilhelmsen, L, Betteridge, J, Birkeland, K, Golay, A, Heine, R, Koranyi, L, Laakso, M, Mokan, M, Norkus, A, Pirags, V, Podar, T, Scheen, A, Scherbaum, W, Schernthaner, G, Schmitz, O, Skrha, J, Smith, U, & Taton, J 2005, 'Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial' The Lancet, vol. 366(9493), s. 1279-1289.

Drewes, A, & Jensen, P 2005, 'Hvad er galdestenssmerter?' Ugeskrift for Læger, vol. 167, nr. 24, s. 2607-2610.

Drewes, A, Reddy, H, Staahl, C, Funch-Jensen, P, Arendt-Nielsen, L, Gregersen, H, & Lundbye-Christensen, S 2005, 'Statistical modeling of the response characteristics of mechanosensitive stimuli in the human esophagus' J Pain, vol. 6, nr. 7, s. 455-462.

Frøkjær, J, Andersen, S, Gale, J, Arendt-Nielsen, L, Gregersen, H, & Drewes, A 2005, 'An experimental study of viscero-visceral hyperalgesia using an ultrasound-based multimodal sensory testing approach' Pain, vol. 119, nr. 1-3, s. 191-200.

Frøkjær, J, Liao, D, Bergmann, A, McMahon, B, Steffensen, E, Drewes, A, & Gregersen, H 2005, 'Three-dimensional biomechanical properties of the human rectum evaluated with magnetic resonance imaging' Neurogastroenterol Motil, vol. 17, nr. 4, s. 531-540.

Frøkjær, J, Larsen, E, Steffensen, E, Nielsen, A, & Drewes, A 2005, 'Magnetic resonance imaging of the small bowel in Crohns disease' Scand J Gastroenterol, vol. 40, nr. 7, s. 832-842.

Gromada, J, Bark, C, Smidt, K, Efanov, A, K., S, Janson, J, Mandic, S, Webb, D, Zhang, W, Meister, B, Jeromin, A, & Berggren, P 2005, 'Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic beta cells through activation of phosphatidylinositol 4-kinase beta' Proc Natl Acad Sci U S A, nr. 102(29), s. 10303-10308.

Hoffmann, H, Bogebjerg, M, Nielsen, L, & Dahl, R 2005, 'Lysis with Saponin improves detection of the response through CD203c and CD63 in the basophil activation test after crosslinking of the high affinity IgE receptor FcepsilonRI' Clin Mol Allergy, vol. 3.

Hollingdal, M, Sturis, J, Gall, M, Damsbo, P, Pincus, S, Veldhuis, J, Porksen, N, Schmitz, O, & Juhl, C 2005, 'Repaglinide treatment amplifies first-phase insulin secretion and high-frequency pulsatile insulin release in Type 2 diabetes' Diabet Med, vol. 22(10), s. 1408-1413.

Jessen, N, Djurhuus, C, Jorgensen, J, Jensen, L, Møller, N, Lund, S, & Schmitz, O 2005, 'Evidence against a role for insulin-signaling proteins PI3-kinase and Akt in insulin resistance in human skeletal muscle induced by short term GH-infusion' Am J Physiol Endocrinol Metab, nr. 288(1), s. 194-199.

Juhl, C, Sturis, J, Hollingdal, M, & Schmitz, O 2005, 'Acute insulin responses to intravenous glucose and GLP-1 are independent of preceding high-frequency insulin pulse-defects induced by glucose entrainment in healthy humans' Horm Metab Res, nr. 37(1), s. 40-44.

Lisby, M, Nielsen, L, & Mainz, J 2005, 'Errors in the medication process: frequency, type, and potential clinical consequences' Int J Qual Health Care, vol. 17(1), s. 15-22.

Lopez-Valverde, V, Andersen, C, Laursen, B, Mulvany, M, & Simonsen, U 2005, 'Glibenclamide reveals role for endothelin in hypoxia-induced vasoconstriction in rat intrapulmonary arteries' J Cardiovasc Pharmacol, vol. 46(4), s. 422-429.

Magnusson, N, Larsen, A, Rungby, J, Kruhøffer, M, Ørntoft, TF, & Stoltenberg, M 2005, 'Bismuth induces cell death in a time and dose dependent manner: GeneChip microarray analysis and autometallography in a rat macrophage cell line' Cell Tiss Res, vol. 321, s. 195-210.

Mari, A, Gastaldelli, A, Natali, A, Ostergard, T, Schmitz, O, & Ferrannini, E 2005, 'Characterization of beta-cell function impairment in first-degree relatives of type 2 diabetic subjects: modeling analysis of 24-h triple-meal tests' Am J Physiol Endocrinol Metab, nr. 288(3), s. 541-546.

Mortensen, L, K., S, Jørgensen, A, Nielsen, J, Laurberg, P, LG, S, & Rungby, J 2005, 'Long-term parathyroid- and C-cell function after radioiodine for benign thyroid diseases' Basic Clin Pharmacol Toxicol, vol. 97, s. 22-8.

Nielsen, B, & Frøbert, O 2005, 'Single coronary artery, ventricular tachycardia, and a family history of sudden death' Cardiol Rev, vol. 13, nr. 5, s. 263-265.

Nielsen, MF, Caumo, A, Aagaard, NK, Chandramouli, V, Schumann, W, Landau, B, O., S, & Vilstrup, H 2005, 'Contribution of defects in glucose uptake to carbohydrate intolerance in liver cirrhosis: Assessment during physiologic glucose and insulin concentrations' Am J Physiol Gastrointest Liver Physiol, vol. 288, s. G1135-43.

Ostergard, T, Ek, J, Hamid, Y, Pedersen, O, Hansen, T, & Schmitz, O 2005, 'Influence of the PPAR-γ2 Pro12Ala and ACE I/D polymorphisms on insulin sensitivity and training effects in healthy offspring of type 2 diabetic subjects' Horm Metab Res, nr. 37(2), s. 99-105.

Pedersen, S, Nyholm, B, Kristensen, K, Nielsen, M, Schmitz, O, & Richelsen, B 2005, 'Increased adiposity and reduced adipose tissue mRNA expression of uncoupling protein-2 in first-degree relatives of type 2 diabetic patients: evidence for insulin stimulation of UCP-2 and UCP-3 gene expression inadipose tissue' Diabetes Obes Metab, nr. 7(1), s. 98-105.

Pold, R, Jensen, L, Jessen, N, Buhl, ES, Schmitz, O, Flyvbjerg, A, Fujii, N, Goodyear, L, Gotfredsen, C, Brand, C, & Lund, S 2005, 'Long-term AICAR administration and exercise prevents diabetes in ZDF rats' Diabetes, nr. 54(4), s. 928-934.

Rejnmark, L, Vestergaard, P, Heickendorff, L, Andreasen, F, & Mosekilde, L 2005, 'Effects of long-term treatment with loop diuretics on bone mineral density, calcitropic hormones and bone turnover' Journal of Internal Medicine, nr. 257, s. 176-184.

Rungby, J, Brock, B, & Schmitz, O 2005, 'New strategies in insulin treatment: analogues and noninvasive routes of administration' Fundam Clin Pharmacol, nr. 19(2), s. 127-132.

Rungby, J, Brock, B, & Schmitz, O 2005, 'New strategies in insulin treatment: Analogues and alternative routes of administration' Fundam Clin Pharmacol, vol. 19, s. 127-32.

Smidt, K, Wogensen, L, Brock, B, Schmitz, O, & Rungby, J 2005, 'Real-time PCR: Housekeeping Genes in the INS-1E Beta-cell Line' Horm Metab Res.

Sondergaard, L, Brock, B, Stoltenberg, M, Flyvbjerg, A, Schmitz, O, Smidt, K, Danscher, G, & Rungby, J 2005, 'Zinc fluxes during acute and chronic exposure of INS-1E cells to increasing glucose levels' Horm Metab Res, vol. 37, s. 133-139.

Vestergaard, M, Pedersen, CB, Christensen, J, Madsen, KM, Olsen, J, & Mortensen, PB 2005, 'Febrile seizures and risk of schizophrenia' Schizophrenia Research, vol. 73, s. 343-349.

Bidrag til videnskabelig bog/antologi

Liao, D, Frøkjær, J, Drewes, A, Gilja, O, Hausken, T, Gregersen, H, & nulletal, R (red.) 2005, 'Three dimentional model analysis in the gastrointestinal tract' i: II International Conference on Computational Engineering, IST Press, Lisbon, Portugal, s. 13-24.

Editorial

Mulvany, M 2005, 'Modeling the vasculature: a judicious approach?' Hypertension, vol. 46, s. 652-653.

Letter/kommentar/debat

Gregersen, H, Drewes, A, & Gilja, O 2005, 'Tension receptors: Theoretical construct or fact?' Gastroenterol, vol. 128, nr. 3, s. 803-804.

Møller, N, Poulsen, L, O., S, Parving, H, & Mogensen, CES 2005, 'HbA1c og type 2 diabetes - hvad er optimalt?' Ugeskr. Læger, vol. 167, nr. 14, s. 1542-1543.

Ph.d.-afhandling

Degn, KB 2005, 'Effects of two GLP-1 mimetics (liraglutide and exenatide) on aspects of glucose and lipid metabolism and islet cell function in humans during daily life conditions and during hypoglycemia' Ph.d.-afhandling, Fællestrykkeriet, Det Sundshedsvidenskabelige Fakultet, Aarhus Universitet, Aarhus.

Koefoed-Nielsen, P 2005, 'Calcineurin phosphatase activity measurements in renal transplant patients treated with cyclosporine and tacrolimus' Ph.d.-afhandling.

LG, S 2005, 'Zinc ions in the pancreas - with special emphasis on β-cells and diabetes' Ph.d.-afhandling.

Lopez-Valverde, V 2005, 'Mechanisms leading to endothelium-dependent Vasodilatation and Vasoconstriction' Ph.d.-afhandling.

Østergaard, T 2005, 'Aspects of insulin resistance and physical fitness in first-degree relatives of patients with type 2 diabetes. The effects of exercise training' Ph.d.-afhandling.

Poster

Brix-Christensen, V, Gjedsted, J, Andersen, SK, Larsson, A, & O., S 2005, 'The inflammatory response during hyperglycemia and hyperinsulinemia in a porcine endotoxemic model' Paper fremlagt ved DASAIM årsmøde, Århus, Danmark. 3. november 2005 - 5. november 2005.

Publiceret abstrakt

Buhl, C, Buhl, ES, Petersen, C, Jessen, N, O., S, & Lund, S 2005, 'No inhibitory effect of TNF alpha on insulin-stimulated glucose uptake in in situ skeletal muscle' Vol. 48, Suppl. 1 udg., Paper fremlagt ved   41st EASD Meeting, Athens, Greece , Grækenland. 10. september 2005 - 15. september 2005, s. A210-A210.

Jensen, L, Nielsen, J, Loefgren, B, Kristiansen, SB, Jessen, N, Nielsen, T, Bøtker, HE, O., S, & Lund, S 2005, 'Metformin activates AMP-activated protein kinase (AMPK) in the rat heart and reduces myocardial infarct size 24 hours later' 48, Suppl. 1 udg., Paper fremlagt ved 41st EASD Meeting, Athens, Greece , Grækenland. 10. september 2005 - 15. september 2005, s. A7-A7.

Mathiassen, O, Olsen, H, M.J., M, Buus, NH, & Christensen, KL 2006, 'Limited forearm volume capacity and preserved dynamic flow resistance during reactive hyperarmia may influence interpretation of forearm minimal vascular resistance' Paper fremlagt ved European Society of Hypertension, Milano, Italien. 17. juni 2005 - 21. juni 2005.

Review

Kirby, M, Jackson, G, & Simonsen, U 2005, 'Endothelial dysfunction links erectile dysfunction to heart disease' Int J Clin Pract, vol. 59(2), s. 225-229.

Laher, I, Mulvany, M, & Henrion, D 2005, 'Meeting report: highlights of the 8th International Symposium on Resistance Arteries' Am J Physiol Heart Circ Physiol, vol. 288(3), s. 1000-1003.

M.J., M 2005, 'Abnormalities of the resistance vasculature in hypertension: correction by vasodilator therapy' Pharmacol Rep, vol. 57 (suppl), s. 144-150.

Saenz De Tejada, I, Angulo, J, Cellek, S, Gonzalez-Cadavid, N, Heaton, J, Prickard, R, & Simonsen, U 2005, 'Pathophysiology of erectile dysfunction' Journal of Sexual Medicine, vol. 2, s. 26-39.