Indholdsfortegnelse Afdelingens årsberetning - forskning - forbrug Publikationerne kan søges i Den Danske Forskningsdatabase

Klinisk Biokemisk Afdeling, Skejby

Forskning

Artikel

Fenger-Eriksen, C, Anker-Møller, E, Heslop, J, Ingerslev, J, & Sørensen, B 2005, 'Thrombelastographic whole blood clot formation after ex vivo addition of plasmasubstitutes: improvements of the induced coagulopathy with fibrinogenconcentrate'. British Journal of Anaesthesia, vol. 94, nr. 3, s. 324-9.

Kristensen, T, Sørensen, P, Kruhøffer, M, Pedersen, K, & Loeschcke, V 2005, 'Genome-wide analysis on inbreeding effects on gene expression in Drosophila melanogaster '. Genetics, vol. 171, s. 157-167.

Sørensen, B, Fenger-Eriksen, C, & Ingerslev, J 2005, 'Recombinant factor VIIa fails to correct coagulopathy induced by haemodilutionwith colloid'. British journal of anaesthesia, vol. 94, nr. 6, s. 862-3.

Artikel peer reviewed

Andersen, CL, Gruszka-Westwood, A, Atkinson, S, Matutes, E, Catovsky, D, Pedersen, R, Pedersen, B, Pulczynski, S, Hokland, P, Jacobsen, E, & Koch, J 2005, 'Recurrent genomic imbalances in B-cell splenic marginal-zone lymphoma revealed by comparative genomic hybridization'. Cancer Genet Cytogenet, vol. 156, nr. 2.

Andersen, LD, Zieger, K, Kruhøffer, M, Andersen, TT, Jensen, JL, Primdahl, H, Aziz, N, Marcussen, N, Jensen, KM, & Ørntoft, TF 2005, 'A molecular signature in superficial bladder carcinoma predicts clinical outcome'. Clinical Cancer Research, vol. 11, nr. 11.

Bartkova, J, Horejsi, Z, Koed, K, Kramer, A, Tort, F, Zieger, K, Guldberg, P, Sehested, M, Nesland, J, Lukas, C, Ørntoft, TF, Lukas, J, & Bartek, J 2005, 'DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis'. Nature, vol. 434, nr. 7035.

Birkenkamp-Demtröder, K, Olesen, S, Sørensen, FB, Laurberg, S, Laiho, P, Aaltonen, L, & Ørntoft, TF 2005, 'Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid'. Gut., vol. 54, nr. 3.

Birkenkamp-Demtröder, K, Wagner, L, Astrup, LB, Sørensen, FB, Gartner, W, Scherubl, H, Heine, B, Christiansen, PMC, & Ørntoft, TF 2005, 'Secretagogin is a novel marker for neuroendocrine differentiation'. Neuroendocrinology, vol. 82, nr. 2, s. 121-138.

Colombo, M, Gregersen, S, Kruhøffer, M, Agger, A, Xiao, J, Jeppesen, PB, Ørntoft, TF, Ploug, T, Galbo, H, & Hermansen, K 2005, 'Prevention of hyperglycemia in Zucker diabetic fatty rats by exercise training: effects on gene expression in insulin-sensitive tissues determined by high-density oligonucleotide microarray analysis'. Metabolism, vol. 54, nr. 12, s. 1571-1581.

Ebbesen, L, & Ingerslev, J 2005, 'Folate deficiency-induced hyperhomocysteinemia attenuates, and folic acid supplementation restores, the functional activities of rat coagulation factors XII, X, and II'. J Nutr, vol. 135, nr. 8, s. 1836-40.

Enver, T, Soneji, S, Joshi, C, Brown, J, Iborra, F, Ørntoft, TF, Andersen, TT, Maltby, E, Smith, K, Abu, DR, Jones, M, Matin, M, Gokhale, P, Draper, J, & Andrews, P 2005, 'Cellular Differentiation Hierarchies In Normal And Culture Adapted Human Embryonic Stem Cells'. Hum.Mol.Genet.

Eschrich, S, Yang, I, Bloom, G, Kwong, K, Boulware, D, Cantor, A, Coppola, D, Kruhøffer, M, Aaltonen, L, Ørntoft, TF, Quakenbush, J, & Yeatman, T 2005, 'Molecular staging for survival prediction of colorectal cancer patients'. J Clin.Oncol, vol. 23, nr. 15.

Ewald, H, Wikman, F, Teruel, B, Buttenschøn, HN, Torralba, M, Als, TD, Daoud, AE, Zacharov, TF, Jørgensen, T, Blanco, L, Kruse, T, Ørntoft, TF, & Mors, O 2005, 'A genome-wide search for risk genes using homozygosity mapping and microarrays with 1,494 single-nucleotide polymorphisms in 22 eastern Cuban families with bipolar disorder'. Am J Med Genet B Neuropsychiatr Genet, vol. 133, nr. 1, s. 25-30.

Harnacke, K, Kruhøffer, M, Ørntoft, TF, & hass, R 2005, 'Down-modulation of poly(ADP-ribose) polymerase-1 (PARP-1) in human TUR leukemia cells restores transcriptional responsiveness for differentiation and cell cycle arrest'. Eur J Cell Biol, vol. 84, nr. 11.

Hvas, A, Gravholt, CH, & Nexø, E 2005, 'Circadian variation of holo-transcobalamin (holo-TC) and related markers'. Clin Chem Lab Med, vol. 43, nr. 7, s. 760-764.

Hvas, A, & Nexo, E 2005, 'Holotranscobalamin--a first choice assay for diagnosing early vitamin B deficiency?'. J Intern Med, vol. 257, nr. 3, s. 289-298.

Ingerslev, J, Christiansen, K, & Sørensen, B 2005, 'Inhibitor to factor VII in severe factor VII deficiency: detection and course of the inhibitory response'. J Thromb Haemost, vol. 3, nr. 4, s. 799-800.

Ingerslev, J 2005, 'Rekombinant factor VIIa ved massiv blødning'. Ugeskr Læger, vol. 167, nr. 25-31, s. 2737.

Ingerslev, J 2005, 'Octocog alfa, plasma/albumin-free method. A Viewpoint by Jørgen Ingerslev'. Drugs, vol. 65, nr. 18, s. 2621-2622.

Jensen, MA, Marcussen, N, Jensen, KM, Andersen, TT, Andersen, LD, & Ørntoft, TF 2005, 'Gene expression profiling of noninvasive primary urothelial tumours using microarray'. Br J Cancer, vol. 93, nr. 10.

Kalbe, L, Leundra, A, Sparre, T, Meulemans, C, Ahn, M, Ørntoft, TF, Kruhøffer, M, Reusens, B, Nerup, J, & Remacle, C 2005, 'Nutritional regulation of proteases involved in fetal rat insulin secretion and islet cell proliferation'. Br.J Nutr, vol. 93, nr. 3.

Koed, K, Wiuf, C, Christensen, LL, Wikman, F, Zieger, K, Jensen, KM, Maase, HVD, & Ørntoft, TF 2005, 'High-density single nucleotide polymorphism array defines novel stage and location-dependent allelic imbalances in human bladder tumors'. Cancer Research, vol. 65, nr. 1.

Kristensen, TN, Sørensen, P, Kruhøffer, M, Pedersen, KS, & Loeschcke, V 2005, 'Genome wide analysis on inbreeding effects on gene expression in Drosophila melanogaster'. Genetics, vol. 171, nr. 1, s. 157-67.

Kruhøffer, M, Ledet-Jensen, J, Laiho, P, Salovaara, R, Sørensen, FB, Arango, D, Demtröder, K, Mecklin, J, Andersen, LD, Järvunen, H, Bech-Knudsen, F, Laurberg, S, Altonen, L, & Ørntoft, TF 2005, 'A classifier for microsatellite-instability status and hereditary non-polyposis colerectal cancer based on gene expression profiling'. British Journal of Cancer, vol. 92, s. 2240-2248.

Kruhøffer, M, Jensen, JL, Laiho, P, Andersen, LD, Salovaara, R, Arango, D, Birkenkamp-Demtröder, K, Christensen, LL, Sørensen, FB, Buhl, L, Mecklin, J, Järvinen, H, Andersen, TT, Wikman, F, Bech-Knudsen, F, Juhola, M, Nupponen, M, Lauerberg, S, Andersen, CL, Aaltonen, L, & Ørntoft, TF 2005, 'Gene expression signatures for colorectal cancer microsatellite status and HNPCC'. British Journal of Cancer, vol. 92, nr. 12.

Lund, L, Møller Ernst-Jensen, K, Tørring, N, & Erik, N 2005, 'Impact of finasteride treatment on perioperative bleeding before transurethral resection of the prostate: a prospective randomized study'. Scand.J Urol.Nephrol, vol. 39, nr. 2.

Magnusson, NE, Cardozo, A, Kruhøffer, M, Eizirik, D, Ørntoft, TF, & Jensen, JL 2005, 'Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis'. BMC Bioinformatics, vol. 6, nr. 1, s. 311.

Magnusson, N, Larsen, A, Rungby, J, Kruhøffer, M, Ørntoft, TF, & Stoltenberg, M 2005, 'Bismuth induces cell death in a time and dose dependent manner: GeneChip microarray analysis and autometallography in a rat macrophage cell line'. Cell Tiss Res, vol. 321, s. 195-210.

Magnusson, NE, Larsen, A, Rungby, J, Kruhøffer, M, Ørntoft, TF, & Stoltenberg, M 2005, 'Gene expression changes induced by bismuth in a macrophage cell line'. Cell Tissue Res, vol. 321, nr. 2, s. 195-210.

Mansilla, F, Hansen, L, Jakobsen, H, Kjeldgaard, N, Clark, BFC, & Knudsen, CR 2005, 'Deconstructing PTI-1: PTI-1 is a truncated, but not mutated, form of translation elongation factor 1A1, eEF1A1'. Biochim Biophys Acta, vol. 1727, nr. 2, s. 116-24.

Mariani, G, Hermann, F, Docle, A, Batorova, A, Etro, D, Peynandi, F, Wulff, K, Schved, J, Auerswald, G, Ingerslev, J, & Bernardi, F 2005, 'Clinical phenotypes and factor VII genotype in congenital factor VII deficiency'. Thromb Haemost, vol. 93, s. 481-487.

Melillo, R, Castellone, M, Guarino, V, De Falco, V, Cerafici, A, Salvatore, G, Caiazzo, F, Basolo, F, Gianini, R, Kruhøffer, M, Ørntoft, TF, Fusco, A, & Santoro, M 2005, 'The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells'. J Clin.Invest., vol. 115, nr. 4.

Memon, AA, Sørensen, BS, Meldgaard, P, Fokdal, L, Andersen, TT, & Nexø, E 2005, 'Down-Regulation of S100C Is Associated with Bladder Cancer Progression and Poor Survival'. Clinical Cancer Research, vol. 11, s. 606-611.

Morkbak, A, Heimdal, R, Emmens, K, Molloy, A, Hvas, A, Schneede, J, Clarke, R, Scott, J, Ueland, P, & Nexo, E 2005, 'Evaluation of the technical performance of novel holotranscobalamin (holoTC) assays in a multicenter European demonstration project'. Clin Chem Lab Med, vol. 43, nr. 10, s. 1058-1064.

Nexo, E, Nooroya, B, Hvas, A, Christensen, A, & Waters, H 2005, 'Autoantibodies against intrinsic factor (IF) measured with an ELISA using recombinant human IF as both catching and detecting reagent'. Clin Chem Lab Med, vol. 34, nr. 4, s. 351-356.

Nielsen, K, Heegaard, S, Vorum, H, Demtröder, K, Ehlers, N, & Ørntoft, TF 2005, 'Altered Expression of CLC, DSG3, EMP3, S100A2, and SLPI in Corneal Epithelium from Keratoconus Patients'. Cornea, nr. 24(6), s. 661-668.

Olesen, S, Christensen, LL, Sørensen, FB, Ørntoft, TF, & Birkenkamp-Demtröder, K 2005, 'Human FK506 binding protein 65 is associated with colorectal cancer'. Mol Cell Proteomics, vol. 4, nr. 4, s. 534-544.

Pallante, P, Berlingieri, M, Troncone, G, Kruhøffer, M, Ørntoft, TF, Viglietto, G, Caleo, A, Migliaccio, I, caussin-Petrucci, M, Santoro, M, Palombini, L, & Fusco, A 2005, 'UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas'. Br.J Cancer, vol. 93.

Ripa, R, Katballe, N, Wikman, F, Jager, A, Bernstein, I, Ørntoft, TF, Schwartz, M, Nielsen, F, & Bisgaard, M 2005, 'Presymptomatic diagnosis using a deletion of a single codon in families with hereditary non-polyposis colorectal cancer'. Mutation Research, vol. 570, nr. 1.

Sørensen, B, & Ingerslev, J 2005, 'Fibrinogen substitution. Anvendelsen ved blødningforårsaget af fibrinogen mangel'. Ugeskr Læger, vol. 167, nr. 25-31, s. 2759-61.

Sørensen, B, & Ingerslev, J 2005, 'Tailoring haemostatic treatment to patient requirements - an update on monitoring haemostatic response using thrombelastography'. Haemophilia, vol. 1, s. 1-6.

Tørring, N, Dagnæs-Hansen, F, Sørensen, BS, Ørntoft, TF, & Nexø, E 2005, 'Increase in amphiregulin and epiregulin in prostate cancer xenograft after androgen deprivation-impact of specific HER1 inhibition'. The Prostate, vol. 64, nr. 1, s. 1-8.

Van dijk, K, Fischer, K, van der Boom, J, Scheibel, E, Ingerslev, J, & van der Berg, H 2005, 'Can long-term prophylaxis for severe haemophilia be stopped in adulthood? Results from Denmark and the Netherlands'. Br J Haematol, vol. 130, nr. 1, s. 107-12.

Zieger, K, Andersen, LD, Wiuf, C, Jensen, JL, Andersen, CL, Jensen, KM, & Ørntoft, TF 2005, 'Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors'. Clin Cancer Res, vol. 11, nr. 21.

Ørntoft, TF 2005, 'Genomic classification of diseases'. Ugeskr.Laeger, vol. 167, nr. 20.

Bidrag til videnskabelig bog/antologi

Andersen, LD, Andersen, CL, Kruhøffer, M, Tørring, N, Koed, K, Wikman, F, Jensen, JL, & Ørntoft, TF 2005, 'DNA microarrays and genetic testing'. i: In Molecular Diagnostics.

Ingerslev, J, Lee, CA, Berntorp, E, & Hoots Eds, WK 2005, 'Laboratory assays in hemophilia'. i: Textbook of Hemophilia, Blackwell Publishing Ltd Massachusetts s. 235-241.

Xiao, J, Kruhøffer, M, Jeppesen, PB, Ørntoft, TF, Abudula, R, & Hermansen, K 2005, 'Changes in gene expression in INS-1 cells: The implication of palmitate in lipotoxicity'. i: In Unraveling lipid metabolism with microarrays, Marcel Dekker, ISBN: 0-8247-5811-0.

Bidrag til videnskabelig rapport

Kruhøffer, M, Magnusson, NE, Jensen, MA, Andersen, LD, & Ørntoft, TF 2005, 'Microarrays for gene expression profiling: Fabrication of Oligonucleotide microarrays, Isolation of RNA, Fluorescent labelling of cRNA, Hybridisation, and Scanning'. i: In Cell Biology 4th edition: A laboratory Manual..

Poster

Sørensen, B, Christiansen, K, Andersen, L, Larsen, L, Norengaard, L, Poulsen, LH, Johansen, P, & Ingerslev, J 2005, 'Visualization of the Continuous APPT Coagulation Signature - Methods and Correlations to Continuous Thrombin Generation'. Paper fremlagt ved The International Society on Thrombosis & Haemostasis XXth Congress and 51st Annual SSC Meeting, Sydney, Australien. 6. august 2005 - 12. august 2005.

Sørensen, B, Larsen, L, Andersen, L, Johansen, P, Poulsen, LH, & Ingerslev, J 2005, 'Visualization of Dynamic Fibrin Formation from APTT Recordings Reflects more Heterogeneity in Patients with severe Haemophilia A than Conventional APTT Values'. Paper fremlagt ved The International Society on Thrombosis and Haemostasis XXth Congress and 51st Annual SSC Meeting, Sydney, Australien. 6. august 2005 - 12. august 2005.

Sørensen, B, Johansen, P, Christiansen, K, Norengaard, L, Larsen, OH, & Ingerslev, J 2005, 'What the Standard APTT Didn't Tell You - Dynamic Plasma Clotting Parameters Reveal Hypercoagulation'. Paper fremlagt ved 47 ^th ASH Annual Meeting and Exposition, Atlanta, USA.