Indholdsfortegnelse Afdelingens årsberetning - forskning - forbrug Publikationerne kan søges i Den Danske Forskningsdatabase

Afdeling for Eksperimentel Klinisk Onkologi

Forskning

Artikel

Eriksen, J, Steiniche, T, & Overgaard, J 2005, 'The role of epidermal growth factor receptor and E-cadherin for the outcome of reduction in the overall treatment time of radiotherapy of supraglottic larynx squamous cell carcinoma.' Acta Oncol, vol. 44, nr. 1, s. 50-8.

Eriksen, JG, Steiniche, T, & Overgaard, J 2005, 'The influence of epidermal growth factor receptor and tumor differentiation on the response to accelerated radiotherapy of squamous cell carcinomas of the head and neck in the randomized DAHANCA 6 and 7 study.' Radiother Oncol, vol. 74, nr. 2, s. 93-100.

Lundby, L, Krogh, K, Jensen, V, Gandrup, P, Qvist, N, Overgaard, J, & Laurberg, S 2005, 'Long-term anorectal dysfunction after postoperative radiotehrapy for rectal cancer' Dis Colon rectum, vol. 48, nr. 7, s. 1343-9.

Artikel peer reviewed

Andreassen, CN 2005, 'Can risk of radiotherapy-induced normal tissue complications be predicted from genetic profiles?' Acta Oncol., vol. 44, nr. 8, s. 801-815.

Andreassen, CN, Alsner, J, Overgaard, J, Herskind, C, Haviland, J, Owen, R, Homewood, J, Bliss, J, & Yarnold, J 2005, ' TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer' Radiother Oncol., vol. 75, nr. 1, s. 18-21.

Bentzen, LN, Vestergaard-Poulsen, P, Nielsen, T, Overgaard, J, Bjørnerud, A, Briley-Sæbø, K, Horsman, MR, & Østergaard, L 2005, 'Intravascular contrast agent-enhanced MRI measuring contrast clearance and tumor blood volume and the effects of vascular modifiers in an experimental tumor' Int J Rad Oncol Biol Phys, nr. 61, s. 1208-1215.

Busk, M, & Boutilier, RG 2005, 'Metabolic arrest and its regulation in anoxic eel hepatocytes' Physiol Biochem Zool., vol. 78, nr. 6, s. 926-936.

Calin, G, Trapasso, F, Shimizu, M, Dumitru, C, Yendamuri, S, Godwin, A, Ferracin, M, Bernardi, G, Chatterjee, D, Baldassarre, G, Rattan, S, Alder, H, Mabuchi, H, Shiraishi, T, Hansen, LL, Overgaard, J, Herlea, V, Mauro, F, Dighiero, G, Movsas, B, Rassenti, L, Kipps, T, Baffa, R, Fusco, A, Mori, M, Russo, G, Liu, C, Neuberg, D, Bullrich, F, Negrini, M, & Croce, C 2005, 'Familial cancer associated with a polymorphism in ARLTS1 ' N. Engl. J. Med., vol. 352, nr. 16, s. 1667-1676.

Chen, G, Jespersen, S, Pedersen, M, Pang, Q, Horsman, MR, & Stødkilde-Jørgensen, H 2005, 'Evaluation of anti-vascular therapy with texture analysis' Anticancer res, vol. 25, nr. 5, s. 3399-3405.

Chen, G, Jespersen, S, Pedersen, M, Qi, P, Horsman, MR, & Stødkilde-Jørgensen, H 2005, 'Intravenous administration of Gd-DTPA prior to DWI does not affect the apparent diffusion constant' Magn Reson Imaging, vol. 23, nr. 5, s. 685-689.

Dagnæs-Hansen, F, & Horsman, M 2005, 'Experience with mouse hepatitis virus sanitation in three transplantable murine tumour lines' Lab Anim, vol. 39, nr. 4, s. 394-399.

Eriksen, JG, Alsner, J, Steiniche, T, & Overgaard, J 2005, 'The possible role of TP53 mutation status in the treatment of squamous cell carcinomas of the head and neck (HNSCC) with radiotherapy with different overall treatment times' Radiother Oncol., vol. 76, nr. 2, s. 135-142.

Eriksen, JG, Steiniche, T, & Overgaard, J 2005, 'The role of epidermal growth factor receptor and E-cadherin for the outcome of reduction in the overall treatment time of radiotherapy of supraglottic larynx squamous cell carcinoma' Acta Oncol., vol. 44, nr. 1, s. 50-58.

Isager, P, Østerlind, A, Engholm, G, Heegaard, S, Lindegaard, J, Overgaard, J, & Storm, H 2005, 'Uveal and conjunctival malignant melanoma in Denmark, 1943-97: incidence and validation study' Ophthalmic Epidemiol., vol. 12, nr. 4, s. 223-232.

Knoop, AS, Knudsen, H, Balslev, E, Rasmussen, BB, Overgaard, J, Nielsen, KV, Schonau, A, Gunnarsdóttir, K, Olsen, KE, Mouridsen, H, & Ejlertsen, B 2005, 'Retrospective Analysis of Topoisomerase IIa Amplifications and Deletions As Predictive Markers in Primary Breast Cancer Patients Randomly Assigned to Cyclophosphamide, Methotrexate, and Fluorouracil or Cyclophosphamide, Epirubicin, and Fluorouracil: Danish Breast Cancer Cooperative Group' J Clin Oncol., vol. 23, nr. 30, s. 7483-7490.

Leach, M, Brindle, K, Evelhoch, J, Griffiths, J, Horsman, MR, Jackson, A, Jayson, C, Judson, I, Knopp, M, Maxwell, R, McIntyre, D, Padhani, A, Price, P, Rathbone, R, Rustin, G, Tofts, P, Tozer, G, Vennart, W, Waterton, J, Williams, S, & Workman, P 2005, 'The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations' Br. J. Cancer, vol. 92, nr. 9, s. 1599-1610.

Lundby, L, Krogh, K, Jensen, V, Gandrup, P, Qvist, N, Overgaard, J, & Laurberg, S 2005, 'Long-term anorectal dysfunction after postoperative radiotherapy for rectal cancer' Dis Colon rectum, vol. 48, nr. 7, s. 1343-1349.

Nielsen, HM, Overgaard, J, Grau, C, Christensen, J, & Overgaard, M 2005, 'Audit of the radiotherapy in the DBCG 82 b&c trials: A validation study of the 1538 patients randomised to postmastectomy radiotherapy' Radiother Oncol., vol. 76, nr. 3, s. 285-292.

Nordsmark, M, Bentzen, S, Rudat, V, Brizel, D, Lartigau, E, Stadler, P, Becker, A, Adam, M, Molls, M, Dunst, J, Terris, D, & Overgaard, J 2005, 'Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy: An international multi-center study' Radiother Oncol., vol. 77, nr. 1, s. 18-24.

Overgaard, J, Eriksen, JG, Nordsmark, M, Alsner, J, & Horsman, M 2005, 'Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer:: Results from the DAHANCA 5 randomised double-blind placebo-controlled trial' Lancet Oncology, vol. 6, nr. 10, s. 757-764.

Rødningen, OK, Overgaard, J, Alsner, J, Hastie, T, & Børresen-Dale, A 2005, 'Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblasts' Radiother Oncol., vol. 77, nr. 3, s. 231-240.

Safwat, A, Schmidt, H, Bastholt, L, Fode, K, Larsen, S, Aggerholm, N, & Maase, HVD 2005, 'A phase II trial of low-dose total body irradiation and subcutaneous Interleukin-2 in metastatic melanoma' Radiother Oncol., vol. 77, nr. 2, s. 143-147.

Sørensen, BS, Hao, J, Overgaard, J, Vorum, H, Honore, B, Alsner, J, & Horsman, M 2005, 'Influence of oxygen concentration and pH on expression of hypoxia induced genes' Radiother Oncol., vol. 76, nr. 2, s. 187-193.

Sørensen, M, Horsman, MR, Cumming, P, Munk, OL, & Keiding, S 2005, 'Effect of intratumoral heterogeneity in oxygenation status on FMISO PET, autoradiography, and electrode PO ₂ measurements in murine tumors' Int J Radiat Oncol Biol Phys., vol. 62, nr. 3, s. 854-861.

Editorial

Overgaard, J 2005, 'Radiotherapy and Oncology comes of age' Radiother Oncol., vol. 75, nr. 1, s. 1-5.

Overgaard, J, & van der Kogel, A 2005, 'ESTRO-Wolfsberg a synergistic approach towards modern radiobiology' Radiother Oncol., vol. 76, nr. 2, s. 109-111.

Foredragsmanuskript/PowerPoint

Alsner, J 2005, 'Radiogenomics - single nucleotide polymorphisms (SNPs) and their effect on the variability in normal tissue radiosensitivity' Paper fremlagt ved 20th ESTRO Meeting on Clinical and Experimental Research in Radiation Oncology (CERRO), les Menuires, Frankrig. 22. januar 2005 - 29. januar 2005.

Busk, M, Overgaard, J, & Horsman, MR 2005, 'WP5 - tumour hypoxia and microenvironment' Paper fremlagt ved BioCare Meeting, Manchester, Storbritannien. 12. oktober 2005 - 13. oktober 2005.

Overgaard, J, Andreassen, CN, & Alsner, J 2005, 'The genetic basis of normal tissue reactions after radiotherapy' Paper fremlagt ved EEMS 2005, 35th Annual Meeting of the European Environmental Mutagen Society, Kos, Grækenland. 3. juli 2005 - 7. juli 2005.

Sørensen, BS, Hao, J, Overgaard, J, Alsner, J, & Horsman, MR 2005, 'HIF-1 upregulated genes as endogenous markers for tumour hypoxia' Paper fremlagt ved Dansk Selskab for Cancerforsknings 18. årsmøde, Vilvorde, Danmark. 4. maj 2005.

Letter/kommentar/debat

Isager, P, Ehlers, N, & Overgaard, J 2005, 'Survival after enucleation and radiation brachy therapy for choroidal and ciliary body melanomas' Acta Ophthalmol Scand., vol. 83, nr. 3, s. 398.

Siemann, DW, Chaplin, DJ, & Horsman, MR 2005, 'Vascular targeting therapies for treatment of malignant disease' Cancer, vol. 104, nr. 1, s. 217.

Poster

Alsner, J, Andreassen, CN, Overgaard, M, & Overgaard, J 2005, 'Correlations between clinical normal tissue radiosensitivity and single nucleotide polymorphisms in ATM , XRCC1 , XRCC3 , APEX , SOD2 , and TGF-B1 ' Paper fremlagt ved Benzon Symposium No. 52, Cellular Responses to DNA Damage, København, Danmark. 22. august 2005 - 25. august 2005.

Horsman, MR 2005, 'Combining OXi 4503 and radiation to improve tumour therapy: the importance of timing, scheduling and drug dose' Paper fremlagt ved AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Philadelphia, USA.

Horsman, MR, Albertella, M, Dunk, C, Harris, P, & Overgaard, J 2005, 'Therapeutic benefit of combining AQ4N with radiation' Paper fremlagt ved ECCO13 - the European Cancer Congress, Paris, Frankrig. 30. oktober 2005 - 3. november 2005.

Kyndi, M, Alsner, J, Hansen, LL, Sørensen, FB, & Overgaard, J 2005, 'Prognostic value of genotypes and LOH at TP53 codon 72 and TP53 mutations in primary breast cancer.' Paper fremlagt ved The Third International Symposium on the Molecular Biology of Breast Cancer, Molde, Norge.

Nielsen, T, Maxwell, R, Stødkilde-Jørgensen, H, & Horsman, MR 2005, 'The efficacy of combretastatin A-4 disodium phosphate in vivo evaluated by dynamic contrast enhanced magnetic resonance imaging' Paper fremlagt ved Danish Society for Cancer Research Annual Meeting, Charlottenlund, Danmark. 4. maj 2005.

Rødningen, OK, Alsner, J, Hastie, T, Overgaard, J, & Børresen-Dale, A 2005, 'Application of microarray analyses to identify genes involved in radiation-induced fibrosis (RIF)' Paper fremlagt ved The Third International Symposium on The Molecular Biology of Breast Cancer, Molde, Norge. 22. juni 2005 - 26. juni 2005.

Publiceret abstrakt

Busk, M 2005, 'Non-invasive microPET imaging of intratumoral oxygenation heterogeneity using 18F-fluoroazomycin arabinoside' Paper fremlagt ved 9th International Tumour Microenvironment Workshop, Oxford, Storbritannien. 20. august 2005 - 22. august 2005.

Horsman, MR, & Hokland, S 2005, 'OXi 4503: a novel vascular targeting agent for improving the response of a C3H mammary carcinoma to hyperthermia' Paper fremlagt ved 22nd Annual Meeting of the European Society for Hyperthermic Oncology, Graz, Østrig, Østerrig. 9. juni 2005 - 11. juni 2005.

Horsman, MR 2005, 'Using OXi 4503 to improve tumour response when combined with therapies in which the tumour microenvironment plays opposing roles.' Paper fremlagt ved 9th International Tumour Microenvironment Workshop, Oxford, Storbritannien. 20. august 2005 - 23. august 2005.

Horsman, MR 2005, 'Vascular targeted therapies' Paper fremlagt ved 1st Scandinavian Medical Education Workshop, Stockholm, Sverige. 15. april 2005 - 16. april 2005.

Kyndi, M, Alsner, J, Hansen, LL, Sørensen, FB, & Overgaard, J 2005, 'Prognostic value of genotypes and LOH at TP53codon 72 and TP53mutations in primary breast cancer' 7(Suppl 2) udg., I Breast Cancer Res., 22. juni 2005 - 26. juni 2005, s. S54.

Nielsen, HM, Overgaard, M, Grau, C, Jensen, AR, & Overgaard, J 2005, 'Risk factors for loco-regional recurrence in breast cancer patients randomized in the DBCG 82 b&c postmastectomy radiotherapy studies and the subsequent prognosis' Paper fremlagt ved ECCO 13 - the European Cancer Congress, Paris, Frankrig. 30. oktober 2005 - 3. november 2005.

Nielsen, T, Maxwell, R, Stødkilde-Jørgensen, H, Østergaard, L, & Horsman, MR 2006, 'Transfer constant and plasma volume fraction in dynamic contrast enhanced magnetic resonance imaging: different dependencies on tumour model, size, and antivascular treatment' Paper fremlagt ved 13th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, Miami, USA. 7. maj 2005 - 13. maj 2005.

Nielsen, T, Murata, R, Maxwell, R, Stødkilde-Jørgensen, H, & Horsman, MR 2005, 'Relationship between combretastatin induced changes in DCEMRI parameters and radiation response in a murine tumour model' Paper fremlagt ved 9th International Tumour Microenvironment Workshop, Oxford, Storbritannien. 20. august 2005 - 23. august 2005.

Rødningen, OK, Alsner, J, Hastie, T, Overgaard, J, & Børresen-Dale, A 2005, 'Application of microarray analyses to identify genes involved in radiation-induced fibrosis (RIF)' 7(Suppl 2) udg., I Breast Cancer Res., 22. juni 2005 - 26. juni 2005, s. S42-S43.

Sørensen, BS, Hao, J, Overgaard, J, Alsner, J, & Horsman, MR 2005, 'Influence of oxygen concentration and pH on expression of hypoxia induced genes' Paper fremlagt ved 9th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology, Ermatingen, Schweiz. 18. juni 2005 - 20. juni 2005.

Sørensen, BS, Hao, J, Overgaard, J, Alsner, J, & Horsman, MR 2005, 'Oxygen dependent expression of endogenous hypoxia markers and the influence of pH' Paper fremlagt ved 9th International Tumour Microenvironment Workshop, Oxford, Storbritannien. 20. august 2005 - 23. august 2005.

Review

Siemann, DW, Bibby, MC, Dark, GG, Dicker, AP, Eskens, FALM, Horsman, MR, Marmé, D, & LoRusso, PM 2005, 'Differentiation and definition of vascular-targeted therapies' Clin Cancer Res., vol. 11, nr. 2 Pt 1, s. 416-420.