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Institut for Medicinsk Biokemi

Forskning

Artikel

Funding, M, Vorum, H, Nexø, E, & Ehlers, N 2005, 'Alpha-1-antitrypsin in aqueous humour from patients with corneal allograft rejection' Acta Ophthalmol Scand, nr. 83, s. 379-384.

Moestrup, SK, & Møller, HJ 2005, 'The iron hormone hepcidin: A future diagnostic marker and therapeutic target in the treatment of anemia and hemochromatosis?' Ugeskrift for Læger, vol. 167, nr. 41, s. 3894-3895.

Artikel peer reviewed

Andersen, OM, Reiche, J, Schmidt, V, Gotthardt, M, Spoelgen, R, Behlke, J, von Arnim, CA, Breiderhoff, T, Jansen, P, Wu, X, Bales, KR, Cappai, R, Masters, CL, Gliemann, J, Mufson, EJ, Hyman, BT, Paul, SM, Nykjær, A, & Willnow, TE 2005, 'Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein' Proc. Natl. Acad. Sci. USA, vol. 102, nr. 38, s. 13461-13466.

Birn, H, Zhai, X, Holm, J, Hansen, SI, Jacobsen, C, Christensen, EI, & Moestrup, SK 2005, 'Megalin binds and mediates cellular internalization of folate binding protein' FEBS Journal, vol. 272, s. 4423-4430.

Chen, ZY, Ieraci, A, Teng, HK, Dall, H, Meng, CX, Herrera, DG, Nykjær, A, Hempstead, BL, & Lee, FS 2005, 'Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway' J. Neurosci., vol. 25, s. 6155-6166.

Conchillo, M, de Knegt, R, Payeras, M, Quiroga, J, Sangro, B, Herrero, J, Castilla-Cortazar, I, Frystyk, J, Flyvbjerg, A, Yoshizawa, C, Jansen, P, Scharschmidt, B, & Prieto, J 2005, 'IGF-I replacement therapy increases albumin concentration in liver cirrhosis: results from a randomized controlled clinical trial' J. Hepatol., vol. 43, s. 630-636.

Coudroy, G, Kozyraki, R, Madsen, M, Trugnan, G, Moestrup, SK, Verroust, PJ, & Maurice, M 2005, 'Contribution of cubilin and amnionless to the processing and membrane targeting of the cubilin-amnionless complex' J. Am. Soc. Nephrol., vol. 16, s. 2330-2337.

Fagoonee, S, Gburek, J, Hisch, E, Marro, S, Moestrup, SK, Laurberg, JM, Christensen, EI, Silengo, L, Altruda, F, & Tolosano, E 2005, 'Plasma haptoglobin modulates iron loading' Am. J. Pathol., vol. 166, s. 973-983.

Fahrenkrug, J, Hannibal, J, Honore, B, & Vorum, H 2005, 'Altered calmodulin responses to light in the suprachiasmatic nucleus of PAC ₁ receptor knockout mice revealed by proteomic analysis' J. Mol. Neurosci., vol. 25, s. 251-258.

Fedosov, S, Fedosova, NU, Berglund, L, Moestrup, SK, Nexø, E, & Petersen, TE 2004, 'Cobalamin induced dimerization of intrinsic factor. I. Structural aspects of the ligand binding and self-assembly' Biochemistry, vol. 43, s. 15095-15102.

Fedosov, S, Fedosova, NU, Berglund, L, Moestrup, SK, Nexø, E, & Petersen, TE 2005, 'Composite organization of the cobalamin binding and cubilin recognition sites of intrinsic factor' Biochemistry, vol. 44, s. 3604-3614.

Funding, M, Vorum, H, Nexø, E, Moestrup, SK, Ehlers, N, & Møller, HJ 2005, 'Soluble CD163 and interleukin 6 are increased in aqueous humor from patients with endothelial rejection of corneal grafts' Acta Ophthalmol. Scand., vol. 83, s. 234-239.

Funding, M, Vorum, H, Nexø, E, Moestrup, SK, Ehlers, N, & Møller, HJ 2005, 'Soluble CD163 and interleukin-6 are increased in aqueous humour from patients with endothelial rejection of corneal grafts' Acta Ophthalmologica Scandinavia, nr. 83, s. 234-239.

Funding, M, Vorum, H, Honore, B, Nexø, E, & Ehlers, N 2005, 'Proteomic analysis of aqueous humour from patients with acute corneal rejection' Acta Ophthalmol Scand, vol. 83, nr. 1, s. 31-39.

Hammes, A, Andreassen, TK, Spoelgen, R, Raila, J, Huebner, N, Schulz, H, Metzger, J, Schweigert, FJ, Luppa, PB, Nykjær, A, & Willnow, TE 2005, 'Role of endocytosis in cellular uptake of sex steroids' Cell, vol. 122, s. 751-762.

He, Q, Madsen, M, Kilkenney, A, Gregory, B, Christensen, EI, Vorum, H, Højrup, P, Schäffer, AA, Tanner, SM, de la Chapelle, A, Giger, U, Moestrup, SK, & Fyfe, JC 2005, 'Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B ₁₂ ) absorption in vivo ' Blood, vol. 106, s. 1447-1453.

Hvidberg, V, Maniecki, MB, Jacobsen, C, Højrup, P, Møller, HJ, & Moestrup, SK 2005, 'Identification of the Receptor Scavenging Hemopexin-Heme Complexes' Blood, nr. 106, s. 2572-2579.

Hvidberg, V, Jacobsen, C, Strong, RK, Cowland, JB, Moestrup, SK, & Borregaard, N 2005, 'The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin (NGAL) with high affinity and mediates its cellular uptake' FEBS Lett., vol. 579, s. 773-777.

Hvidberg, V, Maniecki, MB, Jacobsen, C, Hojrup, P, Moller, HJ, & Moestrup, SK 2005, 'Identification of the receptor scavenging hemopexin-heme complexes' Blood, vol. 106, nr. 7, s. 2572-2579.

Kawasaki, C, Nishi, R, Uekihara, S, Hayano, S, Kragh-Hansen, U, & Otagiri, M 2005, 'How tightly can a drug be bound to a protein and still be removable by charcoal hemoperfusion in overdose cases?' Clin. Toxicol., vol. 43, s. 95-99.

Knudsen, TB, Gustafson, P, Kronborg, G, Kristiansen, TB, Moestrup, SK, Nielsen, JO, Gomes, V, Aaby, P, Lisse, I, Møller, HJ, & Eugen-Olsen, J 2005, 'Soluble hemoglobin scavenger receptor CD163 predicts survival in Tuberculosis' Clin. Microbiol. Infect., vol. 11, s. 730-735.

Knudsen, T, Gustafson, P, Kronborg, G, Christiansen, T, Moestrup, SK, Nielsen, J, Gomed, V, Aaby, P, Lisse, I, Møller, HJ, & Eugen-Olsen, J 2005, 'Predictive value of soluble haemoglobin scavenger receptor CD163 serum levels for survival in verified tuberculosis patients' Clin Mikrobiol Infect, vol. 11, nr. 9, s. 730-735.

Kragh-Hansen, U, Saito, S, Nishi, K, Anraku, M, & Otagiri, M 2005, 'Effect of genetic variation on the thermal stability of human serum albumin' Biochim. Biophys. Acta, vol. 1747, s. 81-88.

Kragh-Hansen, U, Dørge, E, & Pedersen, AO 2005, 'Rate-of-dialysis technique. Theoretical and practical aspects' Anal. Biochem., vol. 340, s. 145-153.

Lindersson, E, Lundvig, DMS, Madsen, PS, Gai, W, Højrup, P, & Jensen, PH 2005, 'P25a stimulate α-synuclein aggregation and is colocalized with aggregated α-synuclein in α-synucleinopathies' J. Biol. Chem., vol. 280, s. 5703-5715.

Lundvig, DMS, Linderson, E, & Jensen, PH 2005, 'Pathogenic effects of α-synuclein aggregation' Molecular Brain Research, vol. 134, nr. 1, s. 3-16.

Ma, S, Anraku, M, Iwao, Y, Yamasaki, K, Kragh-Hansen, U, Yamaotsu, N, Hirono, S, Ikeda, T, & Otagiri, M 2005, 'Hydrolysis of angiotensin II receptor blocker prodrug olmesartan medoxomil by human albumin and identification of its catalytic active sites' Drug Metab. Dispos., vol. 33, s. 1911-1919.

Mahmmoud, YA, Vorum, H, & Cornelius, F 2005, 'Interaction of FXYD10 (PLMS) with Na,K-ATPase from shark rectal glands. Close promimity of Cys74 of FXYD10 to Cys254 in the a domain of the alpha-subunit revealed by intermolecular thiol cross-linking' J. Biol. Chem., vol. 280, nr. 30, s. 27776-27782.

Nielsen, K, Heegaard, S, Vorum, H, Demtröder, K, Ehlers, N, & Ørntoft, TF 2005, 'Altered Expression of CLC, DSG3, EMP3, S100A2, and SLPI in Corneal Epithelium from Keratoconus Patients' Cornea, nr. 24(6), s. 661-668.

Noda, K, Kitami, T, Gai, W, Chegini, F, Jensen, PH, Fujimura, T, Murayama, K, Tanaka, K, Mizuno, Y, & Hattori, N 2005, 'Phosphorylated IkappaBalpha is a component of Lewy body of Parkinson’s disease' Biochem. Biophys. Res. Com., vol. 331, s. 309-317.

Otzen, D, Lundvig, DMS, Wimmer, R, Nielsen, L, Pedersen, J, & Jensen, PH 2005, 'P25alpha is flexible but natively folded and binds tubulin with oligomeric stoichiometry' Protein Sci., vol. 14, s. 1396-1409.

Pihakaski-Maunsbach, K, Tokonabe, S, Vorum, H, Rivard, C, Capasso, J, Berl, T, & Maunsbach, AB 2005, 'The gamma-subunit of Na,K-ATPase is incorporated into plasma membranes of mouse IMCD3 cells in response to hypertonicity.' Am. J. Physiol. Renal Physiol., vol. 288, s. F650-F657.

Schaer, DJ, Schleiffenbaum, B, Kurrer, M, Imhof, A, Bächli, E, Fehr, J, Møller, HJ, Moestrup, SK, & Schaffner, A 2005, 'Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage specific marker of macrophage activation in the hemophagocytic syndrome' Eur. J. Haematol., vol. 74, s. 6-10.

Schaer, D, Schleiffenbaum, B, Kurrer, M, Imhof, A, Bächli, E, Fehr, J, Møller, HJ, Moestrup, SK, & Schaffner, A 2005, 'Soluble hemoglobin - haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome' Eur J Haematol, nr. 74, s. 6-10.

Sørensen, BS, Hao, J, Overgaard, J, Vorum, H, Honore, B, Alsner, J, & Horsman, M 2005, 'Influence of oxygen concentration and pH on expression of hypoxia induced genes' Radiother Oncol., vol. 76, nr. 2, s. 187-193.

Teng, HK, Teng, KK, Lee, R, Wright, S, Tevar, S, Almeida, RD, Kermani, P, Torkin, R, Chen, ZY, Lee, FS, Kraemer, RT, Nykjær, A, & Hempstead, BL 2005, 'ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75 ^NTR and sortilin' J. Neurosci., vol. 25, s. 5455-5463.

Urbonavicius, S, Vorum, H, Urbonaviciene, G, Trumpickas, M, Pavalkis, D, & Honore, B 2005, 'Predictors of post-operative mortality following treatment for non-ruptured abdominal aortic aneyrysm' Curr. Control. Trials Cardiovasc. Med., vol. 6, s. 14.

Vogel, I, Grove, J, Thorsen, P, Moestrup, SK, Uldbjerg, N, & Møller, HJ 2005, 'Preterm delivery predicted by soluble CD163 and CRP in women with symptoms of preterm delivery' Brit. J. Obs. Gyn., vol. 112, s. 737-742.

Vogel, I, Grove, J, Thorsen, P, Moestrup, SK, Uldbjerg, N, & Møller, HJ 2005, 'Preterm delivery predicted by soluble CD163 and CRP in women with symptoms of preterm delivery' Br J Obstet Gynecol, vol. 112, s. 737 - 42.

Wiggers, H, Nielsen, TT, Vorum, H, Honore, B, Randsbæk, F, Kimose, H, Paulsen, PK, & Bøtker, HE 2005, 'Suppressed phospholamban levels differentiate irreversibly dysfunctional from hibernating myocardium in humans' Scand Cardiovasc J, vol. 39, nr. 1-2, s. 55-9.

Review

Moestrup, SK, & Nielsen, LB 2005, 'The role of the kidney in lipid metabolism' Curr. Opin. Lipid., vol. 16, s. 301-306.

Peyre, V, Lair, V, André, V, le Maire, G, Kragh-Hansen, U, le Maire, M, & Møller, JV 2005, 'Detergent binding as a sensor of hydrophobicity and polar interactions in the binding cavities of proteins' Langmuir, vol. 21, s. 8865-8875.