A special event organised by the Department of Molecular Biology and Genetics in association with excellence2012.

17.04.2012

Dato	fre 20 apr
Tid	14:15 — 15:30
Sted	Bartholin Auditorium I at Aarhus University

“Chromatin replication, histone dynamics and epigenome maintenance”

The lecture will be held at:
Bartholin Auditorium I at Aarhus University on Friday 20^th of April 14.15

Professor Anja Groth, Biotech Research and Inovation Centre, Universtity of Copenhagen is recipient of the World Cultural Council 2012 Special Recognition Award.

In dividing cells, faithful duplication of the genome must be accompanied by reproduction of the chromatin landscape on new DNA. Our research focuses on how human cells replicate chromatin and ensure transmission of genetic and epigenetic information during cell division.

Assembly of new DNA into chromatin requires efficient provision of new ‘naïve’ histones along with recycling of old ones that carry information in post-translational modifications. We study how histone chaperones ensure this process. To dissect how specific chromatin structures are restored, we are currently doing proteomic profiling of newly synthesized chromatin. We are also interested in how perturbation of DNA replication impinges on chromatin maintenance, since repair of damaged replication forks can challenge chromatin restoration. Replication stress is frequent in cancer cells, and we are pursuing the idea that replication stress could be a source of epigenetic variation that contributes to tumour heterogeneity.

The lecture will be followed by cake, coffee and drinks and a discussion forum for PhD students and post docs.