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Institut for Klinisk Medicin - Molekylær Medicinsk afdeling (MOMA) - Fakultet: Health

Three-year postdoc in colorectal cancer genomics and circulating tumor DNA research

Ansøgningsfrist 18. jun

Forventet start 1. sep

  • Institut for Klinisk Medicin - Molekylær Medicinsk afdeling (MOMA) Brendstrupgårdsvej 21A 8200 Aarhus N

  • Tidsbegrænset fuldtidsstilling 1. sep 2021 - 31. aug 2024 ID: 6004

Søg stillingen
The Department of Clinical Medicine at Faculty of Health at Aarhus University invites applications for a three year position as Postdoc in the field of  Colorectal Cancer at Department of Molecular Medicine MOMA, Aarhus University Hospital as per 1 September 2021 or as soon as possible thereafter. The position is a three-year fixed-term full-time position.
 

The Group

The colorectal cancer group develops and pioneers new approaches for non-invasive molecular diagnostics for cancer, primarily based on next-generation sequencing (NGS) of circulating cell-free tumor DNA (ctDNA). Led by Professor Claus Lindbjerg Andersen and a team of experienced translational genomics scientists, the lab studies large collections of plasma and other samples from cancer patients through an extensive portfolio of clinical studies and collaborations. We develop NGS analysis tools spanning genome-wide and targeted methods for sensitive detection of tumor-derived nucleic acids and aim to progress these into clinical use by proof-of-concept translational studies to demonstrate their utility. We further explore the biophysical properties of ctDNA to study its origins and interactions and to inform the development of increasingly sensitive methods. The group is a dynamic mix of molecular biologists, bioinformaticians and clinical fellows providing a unique environment for development and learning in cancer genomics and translational research, with a strong focus on clinical application.

We offer a vibrant and stimulating research environment. You will experience challenging projects in translational colorectal cancer research/personalized medicine and you will have the opportunity to develop your scientific skills, disseminate and publish your research.
 

About the research project

As Postdoc you will join the team handling the cancer genomics and ctDNA analyses of the ongoing ctDNA based interventional clinical trials IMPROVE, IMPROVE-IT and IMPROVE-IT2 (clinicaltrials.gov NCT03637686, NCT03748680, NCT04084249). Together the trials cover ~1,800 patients. From each patient we have whole exome sequencing data from matched tumor/normal DNA pairs, and ultra-deep digital-PCR or targeted sequencing data from serial blood samples.
 

Your job responsibilities

As Postdoc in MOMA your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on your project, where you will receive supervision and guidance.

Your main tasks will consist of:
  • Independent research of high international quality, including publication.
  • Participation in daily operation of the trials, including lab work and support of the lab technicians
  • Participation in the weekly analysis of the newly generated tumor/normal whole exome sequencing datasets to identify the somatic genomic alterations that can serve as patient specific biomarkers for detection of ctDNA in the serial blood samples collected in the trials.
  • Optimizing, and potentially developing a new, bioinformatic pipeline for assessing clonality of the somatic genomic alterations identified by whole exome sequencing tumor/normal DNA sequencing.
  • Participation in the group’s effort to develop new strategies and approaches for detection of circulating tumor DNA, including approaches based on whole genomes sequencing (incl. lab work)
  • Develop independent and innovative research projects of high international quality within the field of cancer genomics and circulating tumor DNA.
  • Publication of research findings in top-tier peer-reviewed journals
  • Supervision of Bachelor-, Master- and PhD-students
  • Some degree of contribution towards attracting external research funding.
You will report to the Professor Claus Lindbjerg Andersen
 

Your competences

You have academic qualifications at PhD level or are about to have, preferably within one or more of the following areas molecular biology, medicine, bioinformatics or similar. You have research experience in genomics, and/or epigenomics and/or circulating cell free DNA as well as experience with next generation sequencing. You are rich in initiative, have a strong motivation for research and you have published peer-reviewed articles in international journals.

It is an advantage if you have experience with R, Python or similar programming languages and knowledge about colorectal cancer and/or cancer biology and experience with cancer genomics. Further, experience in medical statistical data analysis (using STATA, R or similar) will also be considered an advantage.

As a person, you are ambitious, take ownership and possess good collaborative, communication and interpersonal skills. We expect you to be fluent in oral and written English.

In order to be assessed as qualified for a Postdoc position, you must meet these academic criteria.

Shortlisting will be used.
 

Questions about the position

If you have any questions about the position, please contact prof. Claus Lindbjerg Andersen tel.: (+45) 78455319 or cla@clin.au.dk.

Your place of work will be the Department of Molecular Medicine, Brendstrupgaardsvej 21, 8200 Aarhus N.


Terms of employment


Application

Your application must include the following:
  • Motivated application
  • Curriculum Vitae
  • Diploma
  • A list of publications
  • A teaching portfolio. We refer to Guideline on the use of teaching portfolios
  • A maximum of five of the publications of greatest relevance to the job may be submitted
  • Template for applicant - postdoc must be completed and uploaded under ‘Extra documents’
  • Strategic research plan can be uploaded
  • Coauthor statement(s) can be uploaded
  • References/recommendations can be uploaded separately in the e-recruitment system

We refer to the faculty’s Guidelines for applicants.

The assessment committee may decide to include non-submitted material in its statement. In such cases, you will be informed and obliged to submit material, unless your application is withdrawn.

All interested candidates are encouraged to apply, regardless of their personal background.


Letter of reference

If you want a referee to upload a letter of reference on your behalf, please state the referee’s contact information when you submit your application. We strongly recommend that you make an agreement with the person in question before you enter the referee’s contact information, and that you ensure that the referee has enough time to write the letter of reference before the application deadline.
Unfortunately, it is not possible to ensure that letters of reference received after the application deadline will be taken into consideration.


International applicant?

Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Please find more information about entering and working in Denmark here. Aarhus University also has a Junior Researcher Development Programme. You can read more about it here.

The application must be submitted via Aarhus University’s recruitment system, which can be accessed under the job advertisement on Aarhus University's website.

Spørgsmål til stillingen?

Claus Lindbjerg Andersen

Claus Lindbjerg Andersen Professor, Institut for Klinisk Medicin - Molekylær Medicinsk afdeling (MOMA) +4578455319 cla@clin.au.dk

Spørgsmål til ansøgning og proces?

Administrationscenter Health - Health HR +4520681396 emply.he.hr@au.dk

Søg stillingen

Ansøgningsfrist: fredag den 18. jun 2021 kl. 23:59 CEST